{"id":117864,"date":"2018-03-11T10:47:33","date_gmt":"2018-03-11T10:47:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistemas-de-liberacion-controlada-de-meropenem\/"},"modified":"2018-03-11T10:47:33","modified_gmt":"2018-03-11T10:47:33","slug":"sistemas-de-liberacion-controlada-de-meropenem","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/complutense-de-madrid\/sistemas-de-liberacion-controlada-de-meropenem\/","title":{"rendered":"Sistemas de liberaci\u00f3n controlada de meropenem"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Fernandez Govantes <\/strong><\/h2>\n<p>La presente tesis doctoral tiene como objetivo el desarrollo de nuevas formulaciones de liberaci\u00f3n controlada de meropenem. El meropenem en un antibi\u00f3tico beta lact\u00e1mico de amplio espectro y de uso hospitalario.  para desarrollar sistemas de liberaci\u00f3n controlada se utilizan como excipientes copol\u00edmeros de \u00e1cido l\u00e1ctico co glic\u00f3lico y t\u00e9cnicas de microencapsulaci\u00f3n incluyendo atomizaci\u00f3n. Se llevan a cabo estudios de caracterizaci\u00f3n in vitro e in vivo. Entre los estudios de laboratorio in vitro se utilizan varias t\u00e9cnicas anal\u00edticas para evaluar las siguientes caracter\u00edsticas de dichas formulaciones: estudios de velocidad de disoluci\u00f3n, estabilidad, tama\u00f1o de part\u00edcula, hplc, gases, etc. Los estudios in vivo incluyen unos primeros experimentos en conejos donde se determinan par\u00e1metros farmacocin\u00e9ticos de cmax, tmax y \u00e1rea bajo la curva de varias formulaciones de meropenem que incluyen formulaciones comercializadas y nuevas formulaciones de liberaci\u00f3n controlada. Por \u00faltimo se administra la formulaci\u00f3n comercializada en pacientes ingresados en la unidad de cuidados intensivos del hospital cl\u00ednico san carlos a diferentes velocidades de perfusi\u00f3n para comprobar c\u00f3mo influye el control de velocidad de entrada del f\u00e1rmaco en las caracter\u00edsticas farmacocin\u00e9ticas. se concluye que las formulaciones de liberaci\u00f3n controlada son \u00fatiles y ventajosas para el tratamiento y prevenci\u00f3n de infecciones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sistemas de liberaci\u00f3n controlada de meropenem<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sistemas de liberaci\u00f3n controlada de meropenem <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Fernandez Govantes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jose Torrado Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda de la paloma Ballesteros papantonakis <\/li>\n<li>M\u00aa \u00e1ngeles Pe\u00f1a fern\u00e1ndez (vocal)<\/li>\n<li> Virto garcia m. rosa (vocal)<\/li>\n<li>m. carmen Frances causape (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Fernandez Govantes La presente tesis doctoral tiene como objetivo el desarrollo de nuevas formulaciones de liberaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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