{"id":117941,"date":"2018-03-11T10:47:38","date_gmt":"2018-03-11T10:47:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-patogenicidad-de-candida-y-de-la-actividad-de-los-farmacos-antifungicos-en-un-modelo-animal-en-caenorhabditis-elegans\/"},"modified":"2018-03-11T10:47:38","modified_gmt":"2018-03-11T10:47:38","slug":"estudio-de-la-patogenicidad-de-candida-y-de-la-actividad-de-los-farmacos-antifungicos-en-un-modelo-animal-en-caenorhabditis-elegans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/levaduras\/estudio-de-la-patogenicidad-de-candida-y-de-la-actividad-de-los-farmacos-antifungicos-en-un-modelo-animal-en-caenorhabditis-elegans\/","title":{"rendered":"Estudio de la patogenicidad de candida y de la actividad de los f\u00e1rmacos antif\u00fangicos en un modelo animal en caenorhabditis elegans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Marcelo Ortega Riveros <\/strong><\/h2>\n<p>En el presente trabajo de tesis doctoral se ha desarrollo un modelo experimental de candidiasis invasora, mediante la infecci\u00c2\u00bfn del nematodo caenorhabditis elegans con las especies de candida que muestran mayor relevancia cl\u00c2\u00bfnica: candida albicans, candida dubliniensis, candida glabrata, candida krusei y las especies integradas en el complejo candida parapsilosis. Se ha estudiado la variabilidad en la virulencia de estas especies mediante an\u00c2\u00bflisis estad\u00c2\u00bfsticos de la supervivencia del nematodo infectado. Adem\u00c2\u00bfs, se ha evaluado la eficiencia de distintos tratamientos con f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos aplicados en monoterapia, tales como anfotericina b, los azoles fluconazol, voriconazol y posaconazol, y las equinocandinas anidulafungina, caspofungina y micafungina. El dimetil sulf\u00c2\u00bfxido se utiliza en la disoluci\u00c2\u00bfn de diversos f\u00c2\u00bfrmacos, entre ellos, algunos f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos, por lo que se ha analizado el efecto de dicho solvente contra caenorhabditis elegans y su posible repercusi\u00c2\u00bfn en la candidiasis experimental. Candida albicans y candida krusei han sido las especies m\u00c2\u00bfs virulentas en este modelo mientras que candida glabrata y candida dubliniensis fueron las menos pat\u00c2\u00bfgenas. La anfotericina b fue muy activa en la terapia de las infecciones por candida. Los tres triazoles estudiados, fluconazol, posaconazol y voriconazol, mostraron una excelente actividad anticandidi\u00c2\u00bfsica. La supervivencia de los nematodos infectados fue menor cuando la candidiasis se trat\u00c2\u00bf con equinocandinas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la patogenicidad de candida y de la actividad de los f\u00e1rmacos antif\u00fangicos en un modelo animal en caenorhabditis elegans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la patogenicidad de candida y de la actividad de los f\u00e1rmacos antif\u00fangicos en un modelo animal en caenorhabditis elegans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Marcelo Ortega Riveros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Eraso Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda jos\u00e9 Linares sicilia <\/li>\n<li>ferran S\u00e1nchez reus (vocal)<\/li>\n<li>Jos\u00e9 Francisco Cano lira (vocal)<\/li>\n<li>nerea Jaureguizar albondigamayor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Marcelo Ortega Riveros En el presente trabajo de tesis doctoral se ha desarrollo un modelo experimental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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