{"id":118189,"date":"2018-03-11T10:48:07","date_gmt":"2018-03-11T10:48:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-de-compuestos-fenolicos-bioactivos-con-ciclodextrinas-y-pola%c2%admeros-de-ciclodextrina\/"},"modified":"2018-03-11T10:48:07","modified_gmt":"2018-03-11T10:48:07","slug":"interaccion-de-compuestos-fenolicos-bioactivos-con-ciclodextrinas-y-pola%c2%admeros-de-ciclodextrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/interaccion-de-compuestos-fenolicos-bioactivos-con-ciclodextrinas-y-pola%c2%admeros-de-ciclodextrina\/","title":{"rendered":"Interacci\u00f3n de compuestos fen\u00f3licos bioactivos con ciclodextrinas y pol\u00edmeros de ciclodextrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marcos Garc\u00eda-padial Alonso <\/strong><\/h2>\n<p>The present phd thesis investigates the interactions of two bioactive antioxidants present in virgin olive oil, tyrosol and caffeic acid, with cyclodextrins and cyclodextrin polymers. Firstly, the interactions of tyrosol with &#946;-, methyl-&#946;- and hydroxypropyl-&#946;-cyclodextrin (hp&#946;cd) have been analysed both in solution and in solid state. The stability constants of the complexes have been determined by uv-spectroscopy and fluorimetry. The characterization of the complexes in solid state has been carried out by x-ray diffraction and differential thermal analysis. Once complexation was verified, the influence of hp&#946;cd on the antioxidant capacity and permeability through membrane of tyrosol and caffeic has been studied. The antioxidant capacity of tyrosol, determined by orac-fluorescein assays, increased in the presence of the cyclodextrin but that of caffeic acid experienced no change. The role of different cyclodextrins on the signal of the orac-fluorescein assay has been evaluated as well. The formation of inclusion complexes with hp&#946;cd decreases the free fraction of the antioxidant and hence the permeability and flux through an artificial membrane. In addition, the sorption and release behavior of tyrosol and caffeic acid on polymeric systems based on cyclodextrins has been studied. Sorption is related to the extent of complexation of each antioxidant. The isosteric heats of sorption determined are higher at low coverages, in accordance with the heterogeneous nature of the polymers. Tyrosol presents higher isosteric heats than caffeic acid. Finally, it has been proved that diffusion is the predominant mechanism of antioxidants release from these cyclodextrin polymers. The microstructure of the polymers is in accordance with their respective release profiles.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacci\u00f3n de compuestos fen\u00f3licos bioactivos con ciclodextrinas y pol\u00edmeros de ciclodextrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacci\u00f3n de compuestos fen\u00f3licos bioactivos con ciclodextrinas y pol\u00edmeros de ciclodextrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marcos Garc\u00eda-padial Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Ar\u00e1nzazu Zornoza Cebeiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  manuel Irache garreta <\/li>\n<li>eneko Larra\u00f1eta landa (vocal)<\/li>\n<li>maite Agueros bazo (vocal)<\/li>\n<li>Antonio  Jos\u00e9 Das neves almeida (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marcos Garc\u00eda-padial Alonso The present phd thesis investigates the interactions of two bioactive antioxidants present in virgin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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