{"id":11865,"date":"2001-02-07T00:00:00","date_gmt":"2001-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-cepas-autoctonas-de-borrelia-burgdorferi-sensu-lato-analisis-de-factores-de-virulencia\/"},"modified":"2001-02-07T00:00:00","modified_gmt":"2001-02-07T00:00:00","slug":"caracterizacion-de-cepas-autoctonas-de-borrelia-burgdorferi-sensu-lato-analisis-de-factores-de-virulencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-de-cepas-autoctonas-de-borrelia-burgdorferi-sensu-lato-analisis-de-factores-de-virulencia\/","title":{"rendered":"Caracterizaci\u00f3n de cepas aut\u00f3ctonas de borrelia, burgdorferi sensu lato. an\u00e1lisis de factores de virulencia."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sellek Cano Ricela Esperanza <\/strong><\/h2>\n<p>Se han estudiado la patogenicidad de 15 cepas aut\u00f3ctonas de borrelia burgdorferi sensu lato en el modelo animal en ratones c3h\/hen, habi\u00e9ndose observado una gran variabilidad. El estudio de los factores de virulencia se ha centrado en la cepa que present\u00f3 una mayor virulencia en dicho modelo (cepa pv6 de b. Garinii).  mediante cultivo seriado in vitro, se han modificado las caracter\u00edsticas de virulencia de dicho aislado. Se han caracterizado los pases obtenidos, que han presentado una disminuci\u00f3n progresiva de patogenicidad hasta su desaparici\u00f3n concluyendo:  qu en la cepa pv6 de b. Garinii, se produjo una reducci\u00f3n de la habilidad de infectar y causar enfermedad en los ratones con el cultivo seriado in vitro. Fue a partir del pase 6 cuando la cepa perdi\u00f3 la capacidad de migrar por la piel y disminuy\u00f3 la capacidad de inducir inflamaci\u00f3n en la att y de producir infecci\u00f3n sist\u00e9mica. Que se observ\u00f3 una correlaci\u00f3n entre dotaci\u00f3n de flgelos y migraci\u00f3n por piel e invasividad. Estas carcter\u00edsticas de patogenicidad disminuyen a partir del pase 6, momento en el que la dotaci\u00f3n flagelos desciende en un 20%.  que se observ\u00f3 una relaci\u00f3n entre presencia del pl\u00e1smido lp25, que contiene el fen ulse, y la inducci\u00f3n de inflamaci\u00f3n en la att. Un 12,5% de los ratones inoculados con el pase 29, sufren inflamaci\u00f3n de la att, correlacionando con una menor presencia de ulse.  que se observ\u00f3 mediante inmunoblot, elisa, rt-pcr y microscopia electr\u00f3nica, una clara asociaci\u00f3n entre la dotaci\u00f3n de flagelos de la cepa pv6 de b. garinni y la capacidad de \u00e9sta de invadir tejidos de hospedador.  que no se observ\u00f3 una relaci\u00f3n directa entre la presencia del pl\u00e1smido lp25 conteniendo el gen ulse y la infectividad de la cepa pv6 de b.Garinii. sin embargo, si se observ\u00f3 una relaci\u00f3n inversa en la intensidad de la banda correspondiente a \u00e9sta prot\u00e9ina y el n\u00famero de pases en cultivo, sugiriendo que en pases altos existe una cierta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de cepas aut\u00f3ctonas de borrelia, burgdorferi sensu lato. an\u00e1lisis de factores de virulencia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de cepas aut\u00f3ctonas de borrelia, burgdorferi sensu lato. an\u00e1lisis de factores de virulencia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sellek Cano Ricela Esperanza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Anda Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Mart\u00ednez peinado <\/li>\n<li> Garc\u00eda monio Juan  Carlos (vocal)<\/li>\n<li>raquel Escudero nieto (vocal)<\/li>\n<li>Antonio Encinas grandes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sellek Cano Ricela Esperanza Se han estudiado la patogenicidad de 15 cepas aut\u00f3ctonas de borrelia burgdorferi sensu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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