{"id":11958,"date":"2001-05-07T00:00:00","date_gmt":"2001-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/experiencia-con-micofenolato-mofetil-en-el-trasplante-renal\/"},"modified":"2001-05-07T00:00:00","modified_gmt":"2001-05-07T00:00:00","slug":"experiencia-con-micofenolato-mofetil-en-el-trasplante-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/experiencia-con-micofenolato-mofetil-en-el-trasplante-renal\/","title":{"rendered":"Experiencia con micofenolato mofetil en el trasplante renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Jose Esteban De La Rosa <\/strong><\/h2>\n<p>Micofenolato mofetil (mmf) es un potente inmunosupresor, libre de efecto nefrot\u00f3xico, eficaz en la prevencion de rechazo agudo y en la nefropatia cronica del trasplante renal. Bloquea la fase de sintesis sobre la estirpe linfocitaria a trav\u00e9s de inhibici\u00f3n selectiva, reversible y no competitiva de la enzima inosin-monofosfato-deshidrogenasa(impdh), clave en la biosintesis de novo de las purinas.  objetivos:se evaluaron tres grupos de trasplantados renales (tr) seg\u00fan la terapia inmunosupresora de mantenimiento p+cya+mmf, grupo estudio,n=31), con el proposito de :  1. Valorar la seguridad clinica de mmf en nuestra poblaci\u00f3n de tr, y en particular en aquellos vhc.  2. Establecer la evolucion de la funcion renal que condiciona mmf asociado a p y cya.  3. Evaluar los efectos de tres tim sobre la evolucion del recuento linficitario y su distribucion en sangre periferica en tres grupos de tr estables, y en particular la modulacion condiciona por mmf.  4. Evaluar la posible utilidad clinica de la monistorizacion de las poblaciones linfocitarias en sangre periferica (plsp) en el tr tratado con mmf.  material y metodo: evaluamos tres grupos de tr seg\u00fan la tim antedicha a traves de un dise\u00f1o observacional no aleatorio con grupos control y seguimiento de doce meses. Registramos caracteristicas basales y variables de seguimiento en los instantes basal, 1\u00c2\u00ba,3\u00c2\u00ba,6\u00c2\u00ba y 12\u00c2\u00ba mes: peso, dosis de inmunosupresores, nivel valle de cya, creatinina s\u00e9rica (crs), hemograma y plsp. En el grupo realiz\u00f3 estudio estadistico descriptivo, analisis factorial y test oportunos, aceptando h1 cuando p&gt;0,05.  resultados:  1. No observamos diferencias entre grupos seg\u00fan edad, sexo, etiolog\u00eda de insuficiencia renal, tiempo de evolucion del trasplante y edad del donante. mmf fue retirado en el 8,8% y registramos un 6,5% de efectos adversos durante el seguimiento.  2. Las dosis empleadas de p y cya en los tres grupos han sido muy homogeneas, con tendenc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Experiencia con micofenolato mofetil en el trasplante renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Experiencia con micofenolato mofetil en el trasplante renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Jose Esteban De La Rosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sebastian Cerezo Morales<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lopez de novales eduardo <\/li>\n<li> Del pino y pino Mar\u00eda  dolores (vocal)<\/li>\n<li>ram\u00f3n Bordes gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Raya mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Jose Esteban De La Rosa Micofenolato mofetil (mmf) es un potente inmunosupresor, libre de efecto nefrot\u00f3xico, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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