{"id":11960,"date":"2001-05-07T00:00:00","date_gmt":"2001-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-de-la-terapia-de-surfactante-exogeno-en-el-transplante-de-pulmon\/"},"modified":"2001-05-07T00:00:00","modified_gmt":"2001-05-07T00:00:00","slug":"utilizacion-de-la-terapia-de-surfactante-exogeno-en-el-transplante-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/utilizacion-de-la-terapia-de-surfactante-exogeno-en-el-transplante-de-pulmon\/","title":{"rendered":"Utilizaci\u00f3n de la terapia de surfactante ex\u00f3geno en el transplante de pulm\u00f3n."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Vali\u00f1o Garc\u00eda <\/strong><\/h2>\n<p>Uno de los principales problemas involucrados en el trasplante pulmonar es el da\u00f1o que sufre el \u00f3rgano trasplantado como consecuencia del proceso de isquemia-reperfusi\u00f3n. La alteraci\u00f3n del surfactante pulmonar pudiera contribuir al cuadro patol\u00f3gico asociado a ese da\u00f1o, que se caracteriza por la aparici\u00f3n de edema, hipertensi\u00f3n e hipoxia pulmonares.  en este trabajo se han descrito las alteraciones en la composici\u00f3n lipo-proteica y en la actividad biof\u00edsica que sufre el surfactante pulmonar como consecuencia del trasplante y se han correlacionado con el empeoramiento de la funcionalidad pulmonar. Se ha propuesto, adem\u00e1s, que el aumento de los niveles de la prote\u00edna reactiva c es un buen marcador del da\u00f1o producido.  asimismo, se han estudiado dos aproximaciones terap\u00e9uticas para paliar las consecuencias del proceso de isquemia-reperfusi\u00f3n: el uso de surfactante pulmonar ex\u00f3geno (alveofact, thomae) administrado mediante instilaci\u00f3n o nebulizaci\u00f3n y el uso en solitario de \u00f3xido n\u00edtrico o administrado simult\u00e1neamente con alveofact. En cuanto a la terapia de surfactante ex\u00f3geno, los resultados obtenidos indican que reduce los da\u00f1os sufridos por el surfactante y que esa reducci\u00f3n se relaciona con una mejora en la funcionalidad pulmonar. aunque ambos m\u00e9todos de administraci\u00f3n son efectivos, la instilaci\u00f3n requiere dosis menores y por ello parce m\u00e1s aplicable en casos cl\u00ednicos. En cuanto a la terapia de \u00f3xido n\u00edtrico, de los resultados se deduce que, adem\u00e1s de ser claramente perjudicial tanto para el surfactante como para la funcionalidad pulmonar cuando se utiliza en solitrio, su administraci\u00f3n conjunta con sufactante ex\u00f3geno revierte los efectos beneficiosos que \u00e9ste tiene. Por lo tanto, es necesario tomar con cautela el empleo sistem\u00e1tico de \u00f3xido n\u00edtrico en el trasplante pulmonar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n de la terapia de surfactante ex\u00f3geno en el transplante de pulm\u00f3n.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n de la terapia de surfactante ex\u00f3geno en el transplante de pulm\u00f3n. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Vali\u00f1o Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cristina Casals Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Vivanco mart\u00ednez <\/li>\n<li> Varela de ugarte Andr\u00e9s (vocal)<\/li>\n<li> Castillo-olivares ramos Jos\u00e9 Luis (vocal)<\/li>\n<li>lourdes Alvarez ayuso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Vali\u00f1o Garc\u00eda Uno de los principales problemas involucrados en el trasplante pulmonar es el da\u00f1o que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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