{"id":11999,"date":"2001-06-07T00:00:00","date_gmt":"2001-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-endotelina-1-en-la-fisiopatogenia-de-la-insuficiencia-renal-en-la-ictericia-obstructiva\/"},"modified":"2001-06-07T00:00:00","modified_gmt":"2001-06-07T00:00:00","slug":"papel-de-la-endotelina-1-en-la-fisiopatogenia-de-la-insuficiencia-renal-en-la-ictericia-obstructiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-endotelina-1-en-la-fisiopatogenia-de-la-insuficiencia-renal-en-la-ictericia-obstructiva\/","title":{"rendered":"Papel de la endotelina-1 en la fisiopatogenia de la insuficiencia renal en la ictericia obstructiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Gomez Alvarez <\/strong><\/h2>\n<p>Los pacientes con ictericia obstructiva presentan con frecuencia insuficiencia renal, en el postoperatorio. Muchos han sido los factores que se han implicado en la genesis de esta complicaci\u00f3n, entre ellos la deplecci\u00f3n de volumen extracelular que ha sido observada por diversos autores. Se ha implicado al p\u00e9ptido natriur\u00e9tico auricular como mediador de los cambios homeost\u00e1ticos que conducirian a la disfunci\u00f3n renal a trav\u00e9s de la deplecci\u00f3n de volumen. como hipotesis, se plantea la posibilidad de que otro p\u00e9ptido, la endotelina-1, participe en la disfunci\u00f3n renal en la ictericia obstructiva. En este sentido, se pretende comprobar si la elevacion del peptido natriuretico auricular es un fenomeno secundario a la posible elevaci\u00f3n del p\u00e9ptido natriur\u00e9tico auricular es un fenomeno secundario a la posible elevacion de la endotelina-1.  con estas premisas se ha llevado a cabo un trabajo experimental desarrollado en ratas wistar, a las que se les realiz\u00f3 ligadura de la via biliar vs. disecci\u00f3n de la v\u00eda biliar sin ligadura de la misma. Los animales fueron introducidos en jaulas metab\u00f3licas durante todo el estudio, para la determinacion diaria del peso, la ingesta de agua y de alimento y la diuresis. Se determinaron diferentes hormonas en plasma (peptido natriuretico auricular (anp), endotelina-1, renina, aldosterona) y en orina (prostaglandina e2). Por otra parte, se han determinado diferentes parametros bioquimicos en plasma y orina.  los resultados de este estudio han mostrado que en el grupo ict\u00e9rico se produjo un descenso en la ingesta de agua y de alimento asi como del peso. los animales a los que se les lig\u00f3 la via biliar mostraron un descenso de la excrecion urinaria de creatinina, sin cambios en el aclaramiento de creatinina. En el mismo grupo se observ\u00f3 un aumento en la concentracion de endotelina-1 y aldosterona sericas asi como de la excrecion urinaria de prostaglandina e2. No se produjeron elevaciones del anp ni de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la endotelina-1 en la fisiopatogenia de la insuficiencia renal en la ictericia obstructiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la endotelina-1 en la fisiopatogenia de la insuficiencia renal en la ictericia obstructiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Gomez Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Pera Madrazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li> Martin ruiz Jos\u00e9 Luis (vocal)<\/li>\n<li>Jos\u00e9 Cantillana Martinez (vocal)<\/li>\n<li>Francisco j. Brice\u00f1o delgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Gomez Alvarez Los pacientes con ictericia obstructiva presentan con frecuencia insuficiencia renal, en el postoperatorio. Muchos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,387,1279,973,139,179],"tags":[2043,39184,10957,13,39329,39183],"class_list":["post-11999","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-abdominal","category-cirugia-experimental","category-cordoba","category-medicina-interna","category-nefrologia","tag-carlos-pera-madrazo","tag-francisco-j-briceno-delgado","tag-jose-cantillana-Martinez","tag-jose-pena-Martinez","tag-manuel-gomez-alvarez","tag-martin-ruiz-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11999"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11999\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}