{"id":12000,"date":"2001-06-07T00:00:00","date_gmt":"2001-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/impacto-cla%c2%adnico-y-economico-de-una-intervencion-farmaceutica-para-promover-eluso-de-la-terapia-secuencial-con-cuatro-antibioticos\/"},"modified":"2001-06-07T00:00:00","modified_gmt":"2001-06-07T00:00:00","slug":"impacto-cla%c2%adnico-y-economico-de-una-intervencion-farmaceutica-para-promover-eluso-de-la-terapia-secuencial-con-cuatro-antibioticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/impacto-cla%c2%adnico-y-economico-de-una-intervencion-farmaceutica-para-promover-eluso-de-la-terapia-secuencial-con-cuatro-antibioticos\/","title":{"rendered":"Impacto cl\u00ednico y econ\u00f3mico de una intervenci\u00f3n farmac\u00e9utica para promover eluso de la terapia secuencial con cuatro antibi\u00f3ticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez V\u00e1zquez M. Jos\u00e9 <\/strong><\/h2>\n<p>El objetivo del presente estudio era evaluar el impacto cl\u00ednico y econ\u00f3mico de una intervenci\u00f3n farmac\u00e9utica para promover el uso de la terapia secuencial con los antibi\u00f3ticos: amoxicilina-\u00e1cido, cefuroxima, ciprofloxacino y clindamicina. dise\u00f1ado como un estudio prospectivo, multic\u00e9ntrico y controlado, incluy\u00f3 un total de 1.479 pacientes que recibieron terapia intravenosa (iv) con algunos de los cuatro antibi\u00f3ticos durante al menos 72 horas. Se establecieron dos grupos: un grupo intervenci\u00f3n (gi) (739 pacientes) en el que se introdujo al tercer d\u00eda de la antibioterapia una hoja informativa recomendado  el tratamiento secuencial y un grupo control (gc) (740 pacientes) sin intervenci\u00f3n.  un total de 905 pacientes (449 gc vs 456 gi) fueron considerados candidatos a realizar tratamiento secuencial. Los grupos fueron homog\u00e9neos respecto al diagn\u00f3stico principal, edad, sexo y gravedad de la infecci\u00f3n. La invervenci\u00f3n increment\u00f3 significativamente el prcentaje de tratamientos secuenciales para los antibi\u00f3ticos amoxicilina-\u00e1cido clavul\u00e1ncio, clindamicina (p&lt;0,0001) y cefuroxima (p&lt;0,05) y para las infecciones respiratoria de v\u00edas bajas, neumon\u00eda y quir\u00fargica. Los efectos adversos asociados a la administraci\u00f3n iv fueron signfificativamente inferiores en los tratamientos secuenciales (p&lt;0,005), siendo superior aunque baja la toxicidad oral (p&lt;0,05). La intervenci\u00f3n consigui\u00f3 reducir significativamente la media de d\u00edas de tratamiento iv (1,2 d\u00edas), con un ahorro significativo para los 905 pacientes de 3.068 pta. (Ic 95% 852-5.284) por tratamiento, siendo el antibi\u00f3tico clindamicina en el que la intervenci\u00f3n result\u00f3 m\u00e1s coste efectiva con una reducci\u00f3n de 1,8 d\u00edas de tratamiento iv y un ahorro de 6.664 pta. (Ic 95% 3.137-10.192) por paciente.  un estudio posterior con ciprofloxacino combin\u00f3 la introducci\u00f3n de la nota informativa con el contacto directo con el m\u00e9dico responsable del paciente obteniend<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Impacto cl\u00ednico y econ\u00f3mico de una intervenci\u00f3n farmac\u00e9utica para promover eluso de la terapia secuencial con cuatro antibi\u00f3ticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Impacto cl\u00ednico y econ\u00f3mico de una intervenci\u00f3n farmac\u00e9utica para promover eluso de la terapia secuencial con cuatro antibi\u00f3ticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez V\u00e1zquez M. Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Laguna Francia M. Reyes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Cadavid torres <\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<li>Francisco Orallo cambeiro (vocal)<\/li>\n<li> Morano amaro Luis enrique (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez V\u00e1zquez M. Jos\u00e9 El objetivo del presente estudio era evaluar el impacto cl\u00ednico y econ\u00f3mico de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[339,82,9,963,36572,2445,957,977,12380],"tags":[6260,39331,2449,39330,39333,39332],"class_list":["post-12000","post","type-post","status-publish","format-standard","hentry","category-analisis-de-farmacos","category-ciencias-economicas","category-ciencias-medicas","category-economia-sectorial","category-estandarizacion-de-farmacos","category-evaluacion-de-farmacos","category-farmacologia","category-santiago-de-compostela","category-sector-de-la-salud","tag-francisco-orallo-cambeiro","tag-laguna-francia-m-reyes","tag-maria-isabel-cadavid-torres","tag-Martinez-vazquez-m-jose","tag-morano-amaro-luis-enrique","tag-rosalia-carron-de-la-calle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12000"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12000\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}