{"id":12034,"date":"2001-06-07T00:00:00","date_gmt":"2001-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-bidimensional-de-antigenos-de-candida-albicans-de-interes-diagnostico\/"},"modified":"2001-06-07T00:00:00","modified_gmt":"2001-06-07T00:00:00","slug":"identificacion-y-caracterizacion-bidimensional-de-antigenos-de-candida-albicans-de-interes-diagnostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/identificacion-y-caracterizacion-bidimensional-de-antigenos-de-candida-albicans-de-interes-diagnostico\/","title":{"rendered":"Identificacion y caracterizacion bidimensional de antigenos de candida albicans de interes diagnostico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Calvo Perez <\/strong><\/h2>\n<p>Las infecciones por candida albicans se han incrementado dramaticamente durante las dos ultimas decadas. Desde un punto de vista diagnostico, la candidiasis invasiva es la que presenta m\u00e1s dificultades debido a la ausencia deuna sintomatolog\u00eda cl\u00ednica especifica, a la imposibilidad de obtener en muchos casos muestras histol\u00f3gicas para la demostraci\u00f3n de la presencia del hongo en el tejido infectado y a la ocurrencia de falsos negativos en los hemocultivos. Por todo ello, el diagnostico serol\u00f3gico, basado bien en el estudio de la respuesta de anticuerpos del paciente, bien en la deteccion de antigenos circulantes y metabolitos fungicos, se ha visto impulsado en los ultimos a\u00f1os en un intento de identificar marcadores serologicos de la candidiasis invasiva. Sin embargo, esta identificacion resulta complicada debido a la complejidad y variabilidad de la composici\u00f3n antigenica de candida albicans. Asi, la electroforesis bidimensional (2-de) basada en el fraccionamiento acoplado a la carga y el peso molecular de los proteinas ha demostrado ser una herramienta muy util en el analisis de mezclas complejas de proteinas de candida. La combinaci\u00f3n de esta tecnica de separacion electroforetica con la inmunodetecci\u00f3n mediante western blot y revelado con quimioluminiscencia frente a distintos antisueros animales, humanos, anticuerpos monoclonales y lectinas, ha permitido llevar a cabo el objetivo principal del presente trabajo, la identificacion y caracterizacion de proteinas de candida albicans mediante 2-de en busca de posibles marcadores antigenicos de la candidiasis invasiva. De esta manera, de los aproximadamente 700 p\u00e9ptidos resueltos en los mapas proteicos en dos dimensiones, se han considerado antigenos de interes diagnostico por presentar una marcada respuesta de anticuerpos en los pacientes con candidiasis invasiva pero ninguna o muy poca en las personas sanas, catorce antigenos de naturaleza manoproteica y cuyos epitopos de reconoci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion y caracterizacion bidimensional de antigenos de candida albicans de interes diagnostico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion y caracterizacion bidimensional de antigenos de candida albicans de interes diagnostico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Calvo Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Hernando Echevarria Fernando Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>pilar Arevalo morales (vocal)<\/li>\n<li> Rubio calvo M\u00aa del carmen (vocal)<\/li>\n<li> Ponton san emeterio Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Calvo Perez Las infecciones por candida albicans se han incrementado dramaticamente durante las dos ultimas decadas. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1738,35,1737,2612,984,278,12909],"tags":[39436,28094,39437,5149,5148,39438],"class_list":["post-12034","post","type-post","status-publish","format-standard","hentry","category-antigenos","category-ciencias-de-la-vida","category-inmunologia","category-inmunoquimica","category-levaduras","category-microbiologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-esther-calvo-perez","tag-hernando-echevarria-fernando-luis","tag-pilar-arevalo-morales","tag-ponton-san-emeterio-jose","tag-ramon-cisterna-cancer","tag-rubio-calvo-ma-del-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12034"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12034\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}