{"id":12122,"date":"2001-10-07T00:00:00","date_gmt":"2001-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cetogenesis-en-astrocitos-caracterizacion-regulacion-y-posible-papel-citoprotector\/"},"modified":"2001-10-07T00:00:00","modified_gmt":"2001-10-07T00:00:00","slug":"cetogenesis-en-astrocitos-caracterizacion-regulacion-y-posible-papel-citoprotector","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/cetogenesis-en-astrocitos-caracterizacion-regulacion-y-posible-papel-citoprotector\/","title":{"rendered":"Cetogenesis en astrocitos: caracterizacion, regulacion y posible papel citoprotector"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Blazquez Ortiz <\/strong><\/h2>\n<p>Los cuerpos cetonicos pueden reemplazar a la glucosa como principal fuente energetica cerebral en situaciones en las que est\u00e1 es escasa. Aunque se ha asumido que el higado es el organo que aporta cuerpos cetonicos a los tejidos extrahepaticos, existian algunas evidencias en la bibliografia de que los astrocitos tambien son capaces de producirlos. Asi, en este trabajo se ha tratado de caracterizar la ruta cetogenica en astrocitos, estudiar sus mecanismos de regulacion, y evaluar su posible papel citoprotector en situaciones patologicas, como la hipoxia y la apoptosis inducida por acidos grasos. A partir de los resultados obtenidos y a modo de resumen, pueden extraerse las siguientes conclusiones generales:  1,- los astrocitos son capaces de producir cantidades significativas de cuerpos cet\u00f3nicos, que podrian ser cedidos a las neuronas para ser utilizados como fuente energetica alternativa a la glucosa. Las propiedades de la cetogenesis en astrocitos son muy semejantes a las de la cetogenesis en hepatocitos, lo cual apoya una posible funcionalidad biologica de aquella.  2.-La cetogenesis en astrocitos es un proceso flexible, y se encuentra finamente regulado por al menos dos proteina quinasas, la pka y la ampk. as\u00ed, un incremento en la concentracion de camp (que activa la pka) o de amp (que activa la ampk) estimula la producci\u00f3n de cuerpos cet\u00f3nicos por inactivaci\u00f3n de la acc, descenso en la concentracion de malonil-coa y desinhibicion de la cpt-i. Ademas, la accion activadora directa de la ceramida sobre la cpt-i estimula la produccion de cuerpos cetonicos.  3.- La ampk astrogial podria ejercer un papel ciprotector en situaciones de hipoxia(aumentando el aporte de cuerpos cet\u00f3nicos a las neuronas) y apoptosis inducida por acidos grasos (inhibiendo la sintesis de novo de ceramida). La cetogenesis astroglial tambien podrian impedir algunos de los efectos perjudiciales provocados por la acumulacion de acidos grasos en el cerebro. Asi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cetogenesis en astrocitos: caracterizacion, regulacion y posible papel citoprotector<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cetogenesis en astrocitos: caracterizacion, regulacion y posible papel citoprotector <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Blazquez Ortiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Guzm\u00e1n Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  teresa Miras portugal <\/li>\n<li>sebasti\u00e1n Cerd\u00e1n Garc\u00eda-esteller (vocal)<\/li>\n<li>Francisco Luis Moreno mu\u00f1oz (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Blazquez Ortiz Los cuerpos cetonicos pueden reemplazar a la glucosa como principal fuente energetica cerebral en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[39706,29532,5664,39707,2615,39708],"class_list":["post-12122","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-cristina-blazquez-ortiz","tag-francisco-luis-moreno-munoz","tag-lisardo-bosca-gomar","tag-manuel-guzman-pastor","tag-maria-teresa-miras-portugal","tag-sebastian-cerdan-garcia-esteller"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12122"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12122\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}