{"id":12169,"date":"2001-11-07T00:00:00","date_gmt":"2001-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-vasodilatadores-del-no-y-dadores-de-no-en-arterias-pulmonares-y-mesentericas-de-lechon-modulacion-por-estres-oxidativo\/"},"modified":"2001-11-07T00:00:00","modified_gmt":"2001-11-07T00:00:00","slug":"efectos-vasodilatadores-del-no-y-dadores-de-no-en-arterias-pulmonares-y-mesentericas-de-lechon-modulacion-por-estres-oxidativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-vasodilatadores-del-no-y-dadores-de-no-en-arterias-pulmonares-y-mesentericas-de-lechon-modulacion-por-estres-oxidativo\/","title":{"rendered":"Efectos vasodilatadores del no y dadores de no en arterias pulmonares y mesent\u00e9ricas de lech\u00f3n: modulaci\u00f3n por estr\u00e9s oxidativo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez L\u00f3pez Jos\u00e9 Gustavo <\/strong><\/h2>\n<p>La hipertensi\u00f3n pulmonar persistente neonatal (hppn) se ha asociado a alteraciones en la v\u00eda del \u00f3xido n\u00edtrico (no)\/gmp c\u00edclico en las arterias pulmonares. En pacientes con hppn, el tratamiento con no inhalado reduce las resistencias vasculares pulmonares y aumenta el flujo sangu\u00edneo pulmonar, aunque resulta infectivo en, aproximadamente, la mitad de los pacientes. una posible explicaci\u00f3n para la alteraci\u00f3n de la v\u00eda del no en la hppn y para el fallo terap\u00e9utico del no inhalado podr\u00eda ser un aumento en la producci\u00f3n end\u00f3gena de super\u00f3xido.  por lo anterior, en la presente tesis doctoral, se estudiaron los efectos vasodilatadores del no y de los donadores de no (snap y snp), as\u00ed como su modulaci\u00f3n por parte de agentes pro- y antioxidantes (que aumentan y disminuyeron la concentraci\u00f3n del radical super\u00f3xido , respectivamente).  se utilizaron arterias pulmonares aisladas de lechones de 1 d\u00eda y de 2 semanas de edad. Se realiz\u00f3 el registro de la fuerza contr\u00e1ctil de los anillos arteriales y se cuantific\u00f3 la concentraci\u00f3n de no por un electrodo amperom\u00e9trico.  nuestros resultados indican que en las arterias pulmonares de lech\u00f3n se produce un aumento con la edad en la respuesta al no, posiblemente, relacionado con una actividad elevada de la cilooxigenasa en los primeros momentos de vida. La nad (p)h oxidasa de la capa adventicia genera radical super\u00f3xido, capaz de inactivar el no, independientemente de la edad. A diferencia de los resultados obtenidos con el no, el efecto relajante inducido por los donadores de no se ve afectado levemente o no se afecta por el radical super\u00f3xido end\u00f3geno, e incluso cuando \u00e9ste se incrementa la inhibir la super\u00f3xido dismutasa.  a la vista de los resultados de la presente tesis doctoral, proponemos que el estr\u00e9s oxidativo modula la acci\u00f3n vasodilatadora del no, pero no la de los donadores de no. Esto podr\u00eda ser debido a que el snap y el snp liberar\u00edan no a un compartimento di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos vasodilatadores del no y dadores de no en arterias pulmonares y mesent\u00e9ricas de lech\u00f3n: modulaci\u00f3n por estr\u00e9s oxidativo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos vasodilatadores del no y dadores de no en arterias pulmonares y mesent\u00e9ricas de lech\u00f3n: modulaci\u00f3n por estr\u00e9s oxidativo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez L\u00f3pez Jos\u00e9 Gustavo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Tamargo Men\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Moreno gonzalez <\/li>\n<li>Mar\u00eda  Jes\u00fas Alonso gordo (vocal)<\/li>\n<li>elisa Marhuenda requena (vocal)<\/li>\n<li>Jos\u00e9 Jim\u00e9nez mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez L\u00f3pez Jos\u00e9 Gustavo La hipertensi\u00f3n pulmonar persistente neonatal (hppn) se ha asociado a alteraciones en la 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