{"id":12193,"date":"2001-12-07T00:00:00","date_gmt":"2001-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-anatomocla%c2%adnico-y-fisiopatologico-de-una-serie-de-85-pacientes-con-esteatohepatitis-no-alcoholica\/"},"modified":"2001-12-07T00:00:00","modified_gmt":"2001-12-07T00:00:00","slug":"estudio-anatomocla%c2%adnico-y-fisiopatologico-de-una-serie-de-85-pacientes-con-esteatohepatitis-no-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-anatomocla%c2%adnico-y-fisiopatologico-de-una-serie-de-85-pacientes-con-esteatohepatitis-no-alcoholica\/","title":{"rendered":"Estudio anatomocl\u00ednico y fisiopatol\u00f3gico de una serie de 85 pacientes con esteatohepatitis no alcoh\u00f3lica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  P\u00e9rez Carreras M. Mercedes <\/strong><\/h2>\n<p>La esteatohepatitis no alcoh\u00f3lica (ehna) es una entidad cl\u00ednico-morfol\u00f3gica de etiolog\u00eda no conocida que se caracteriza por la presencia en el h\u00edgado de lesiones similares a las producidas por el alcohol, pero en ausencia de exposici\u00f3n a este t\u00f3xico.  objetivos  1,- definir las caracter\u00edsticas anatomocl\u00ednicas de la ehna.  2,- investigar algunas de las hip\u00f3tesis patog\u00e9nicas de la ehna: alteraci\u00f3n de los mecanismos de transporte de los \u00e1cidos grasos libres al interior mitocondrial, disfunci\u00f3n de la cadena respiratoria mitocondrial crm, papel de la insulina, el sobrecrecimiento bacteriano intestinal sbi y del tnf alfa, alteraci\u00f3n en el metabolismo del hierro y mutaciones del gen de la hemocromatosis hfe, y la posible participaci\u00f3n de factores gen\u00e9ticos ligados al hla.  material  sujetos: 85 pacientes consecutivos con ehna. En todos ellos se recogieron los datos seg\u00fan un protocolo cl\u00ednico, histopatol\u00f3gico y de investigaci\u00f3n.  controles: grupo 1: 16 sujetos en los que se obtuvo una cu\u00f1a hep\u00e1tica durante una cirug\u00eda abdominal; grupo 2: 22 sujetos en quienes se efectuaron las determinaciones en sangre perif\u00e9rica de glucosa, insulina, p\u00e9ptido c y glucag\u00f3n.  metodos  el contenido hep\u00e1tico de c arnitina y \u00e9steres se midi\u00f3 por m\u00e9todo radiqu\u00edmico y la actividad de la cpt por intercambio isot\u00f3pico. La actividad de los 5 complejos enzim\u00e1ticos de la crm en tejido hep\u00e1tico se determin\u00f3 por espectrofotometr\u00eda.La insulinemia mediante enzimoinmunoensayo de micropart\u00edculas, el p\u00e9ptido c por inmunoensayo competitivo quimioluminiscente y el glucag\u00f3npor radioinmunoensayo secuencial de doble anticuerpo. Se calcul\u00f3 la insulinorresistencia, la secreci\u00f3npancre\u00e1tica y la extracci\u00f3n hep\u00e1tica de insulina seg\u00fan el cociente molar glucosa\/insulina, glucosa\/p\u00e9ptido c y p\u00e9ptido c\/insulina, respectivamente. se investigo el sbi mediante el test del hidr\u00f3geno espirado tras la administraci\u00f3n de glucosa. Se cuantific\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio anatomocl\u00ednico y fisiopatol\u00f3gico de una serie de 85 pacientes con esteatohepatitis no alcoh\u00f3lica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio anatomocl\u00ednico y fisiopatol\u00f3gico de una serie de 85 pacientes con esteatohepatitis no alcoh\u00f3lica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  P\u00e9rez Carreras M. Mercedes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Solis  Herruzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Enr\u00edquez de salamanca lorente <\/li>\n<li>agust\u00edn Albillos mart\u00ednez (vocal)<\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<li>carmelo Garc\u00eda monz\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de P\u00e9rez Carreras M. Mercedes La esteatohepatitis no alcoh\u00f3lica (ehna) es una entidad cl\u00ednico-morfol\u00f3gica de etiolog\u00eda no conocida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139],"tags":[31696,39923,22624,39922,7556,13202],"class_list":["post-12193","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","tag-agustin-albillos-Martinez","tag-carmelo-garcia-monzon","tag-jose-antonio-solis-herruzo","tag-perez-carreras-m-mercedes","tag-rafael-enriquez-de-salamanca-lorente","tag-ricardo-moreno-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12193"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12193\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}