{"id":12236,"date":"2018-03-09T08:58:00","date_gmt":"2018-03-09T08:58:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/carcinoma-epidermoide-de-cabeza-y-cuello-evaluacion-pronostica-de-micrometastasis-indice-de-proliferacion-y-alteraciones-geneticas\/"},"modified":"2018-03-09T08:58:00","modified_gmt":"2018-03-09T08:58:00","slug":"carcinoma-epidermoide-de-cabeza-y-cuello-evaluacion-pronostica-de-micrometastasis-indice-de-proliferacion-y-alteraciones-geneticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/carcinoma-epidermoide-de-cabeza-y-cuello-evaluacion-pronostica-de-micrometastasis-indice-de-proliferacion-y-alteraciones-geneticas\/","title":{"rendered":"Carcinoma epidermoide de cabeza y cuello: evaluacion pronostica de micrometastasis, indice de proliferacion y alteraciones geneticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M Dolores Arias Santos <\/strong><\/h2>\n<p>Se estudiaron 49 pacientes con carcinoma epidermoide de cabeza  y cuello (cecc) sometidos a vaciamiento ganglionar cervical con los siguientes objetivos: 1)determinar la frecuencia y posible interes pronostico de micromet\u00e1stasis ganglionares; 2)estudiar la presencia de celulas intersticiales reticulares citoqueratina positivas (circs); 3) estudiar el valor pron\u00f3stico del indice de proliferacion (mib1) y de la expresi\u00f3n de p53 del tumor primario, 4) determinar la posible existencia de diferencias biologicas entre las poblaciones celulares primitiva y metastasica, comparando los dos parametros antedichos, 5) a nivel genetico, estudiar la presencia y valor pron\u00f3stico de mutaciones de p53, inestabilidad de microsat\u00e9lites (im) y perdida de heterocigosidad (loh) en cecc primarios.  los resultados demuestran que la tinci\u00f3n inmunohistoqu\u00edmica con citoqueratinas permite detectar micromet\u00e1stasis en el 16,6% de los pacientes con cecc en estudio no. La presencia de circs es muy frecuente y puede suponer una fuente de falsos positivos en la deteccion de micromet\u00e1stasis mediante m\u00e9todos no morfol\u00f3gicos de detecci\u00f3n de citoqueratinas, como la pcr. Los pacientes con alto \u00edndice de proliferaci\u00f3n en el tumor primario presentan mayor frecuencia de met\u00e1stasis, pero no hay una relaci\u00f3n estadisticamente significativa. No se observa correlaci\u00f3n estad\u00edsticamente significativa entre ning\u00fan parametro clinico y los indices de proliferaci\u00f3n y de expresi\u00f3n de p53. No hay diferencias significativas entre la poblaci\u00f3n primitiva y metast\u00e1sica con respecto a estos \u00edndices. Las mutaciones del gen de p53 se observan en alrededor del 17% de los casos de cecc y no se correlacionan significativamente con los parametros clinicos ni con la detecci\u00f3n inmunohistoqu\u00edmica de p53. La im se encuentra en casi el 20% de los cecc y la loh en el 71%. la loh se correlaciona con la localizaci\u00f3n del tumor primario y con el grado de diferenciaci\u00f3n histol\u00f3gica. La<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Carcinoma epidermoide de cabeza y cuello: evaluacion pronostica de micrometastasis, indice de proliferacion y alteraciones geneticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Carcinoma epidermoide de cabeza y cuello: evaluacion pronostica de micrometastasis, indice de proliferacion y alteraciones geneticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M Dolores Arias Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Forteza Vila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andr\u00e9s Beiras iglesias <\/li>\n<li>giovanna Cenacchi (vocal)<\/li>\n<li>horacio Oliva aldamiz (vocal)<\/li>\n<li>Andr\u00e9s Soto varela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M Dolores Arias Santos Se estudiaron 49 pacientes con carcinoma epidermoide de cabeza y cuello (cecc) sometidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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