{"id":12244,"date":"2018-03-09T08:58:00","date_gmt":"2018-03-09T08:58:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-gen-de-la-quinada-jnk-sapk-alfa-de-raton\/"},"modified":"2018-03-09T08:58:00","modified_gmt":"2018-03-09T08:58:00","slug":"caracterizacion-del-gen-de-la-quinada-jnk-sapk-alfa-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-del-gen-de-la-quinada-jnk-sapk-alfa-de-raton\/","title":{"rendered":"Caracterizacion del gen de la quinada jnk\/sapk, alfa de raton"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ainhoa Itziar Callejo De Prado <\/strong><\/h2>\n<p>Las quinasas activadas por se\u00f1ales extracelulares (erks) constituyen una superfamilia de proteinas cuyos componentes se agrupan en tres principales familias: erk\/mapk, jnk\/sapk y p38mapk. Estas familias descriten tres rutas de transducci\u00f3n de se\u00f1al en respuesta a gran variedad de est\u00edmulos (mitogenicos y de tipo estr\u00e9s). Estas rutas se inician a nivel de la membrana celular gracias a la percepci\u00f3n del cambio extracelular, se interiorizan y progresan en el citoplasma gracias a la activaci\u00f3n en cascada de los componentes de la ruta por fenomenos de fosforilaci\u00f3n reversible, y alcanzan el nucleo donde se verifica un cambio en el patr\u00f3n de expresi\u00f3n genica que se traduce en una respuesta celular frente al est\u00edmulo. Las funciones celulares en las que se encuentran involucradas estas rutas son: proliferaci\u00f3n y diferenciaci\u00f3n celular (erk\/mapk) y parada de ciclo celular, reparaci\u00f3n del da\u00f1o genetico y entrada en apoptosis(knk\/sapk y p38mapk) y parada del ciclo celular, reparaci\u00f3n del da\u00f1o genetico y entrada en apoptosis (jnk\/sapk y p38mapk).  esta memoria de tesis centra su estudio en la caracterizaci\u00f3n del gen de una isoforma de las quinasas activadas por estr\u00e9s celular, jnk\/sapka. En dicha memoria se detallan las caracteristicas m\u00e1s destacadas del gen de esta quinasa en rat\u00f3n:  se trata de un gen de alrededor de 36kpb, que consta de 13 exones que representan apenas un 8% de la secuencia completa y 12 intrones de tama\u00f1os muy variables. el cod\u00f3n de inicio de la traducci\u00f3n de localiza en el segundo ex\u00f3n, y el cod\u00f3n de fin de la traducci\u00f3n en el ultimo. El primer exon es pues zona transcrita del cdna pero no codificante. Tres de los exones centrales del gen estan implicados en la genesis de las cuatro variantes descritas para la isoforma alfa de raton. La quinasa jnk\/sapka posee 423 aminoacidos y su configuracion espacial\/tridimensional guarda un modelo estructural comun con el resto de otras quinasas erks.  se ha iden<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion del gen de la quinada jnk\/sapk, alfa de raton<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion del gen de la quinada jnk\/sapk, alfa de raton <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ainhoa Itziar Callejo De Prado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Chinchetru Manero Miguel A.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arsenio Fernandez lopez <\/li>\n<li>Jos\u00e9 Carlos Rodriguez rey (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Luengo rodr\u00edguez (vocal)<\/li>\n<li>daniel Zamanillo castanedo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ainhoa Itziar Callejo De Prado Las quinasas activadas por se\u00f1ales extracelulares (erks) constituyen una superfamilia de proteinas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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