{"id":12251,"date":"2018-03-09T08:58:01","date_gmt":"2018-03-09T08:58:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/comportamiento-farmacocinetico-de-la-marbofloxacina-en-cabras\/"},"modified":"2018-03-09T08:58:01","modified_gmt":"2018-03-09T08:58:01","slug":"comportamiento-farmacocinetico-de-la-marbofloxacina-en-cabras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/comportamiento-farmacocinetico-de-la-marbofloxacina-en-cabras\/","title":{"rendered":"Comportamiento farmacocin\u00e9tico de la marbofloxacina en cabras"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Samanta Waxman Dova <\/strong><\/h2>\n<p>La marbofloxacina, un antimicrobiano del grupo de las fluoroquinolonas desarrollado exclusivamente para uso veterinario, ha demostrado poseer unas caracter\u00edsticas farmacocin\u00e9ticas adecuadas para su uso en diversas especies.  el objetivo de este trabajo fue definir el comportamiento farmacocin\u00e9tico de la marbofloxacina en cabras. Para ello se estudi\u00f3 la disposici\u00f3n del f\u00e1rmaco tras la administraci\u00f3n intravenosa,intramuscular y subcut\u00e1nea y la posible influencia del desarrollo o el padecimiento de un cuadro febril en las caracter\u00edsticas farmacocin\u00e9ticas.  tras la adminsitraci\u00f3n intravenosa, la marbofloxacina present\u00f3 una amplia distribuci\u00f3n (vss = 1,31 l\/kg), una eliminaci\u00f3n relativaemnte lenta (ci = 0,23 i\/kg.H) y, consecuentemente, una prolongada permanencia en el organismo (mrt = 5,06 h). Administrada por v\u00eda intramuscular y subcut\u00e1nea, present\u00f3 una alta biodisponibilidad (f=107,56% y 97,96%, respectivamente) y, al igual que tras la administraci\u00f3n intravenosa, una prolongada permanencia en el organismo (mrt=5,44 y 4,56 h, respectivamente).  el desarroll\u00f3 influy\u00f3 en el comportamiento farmacocin\u00e9tico de la marbofloxacina, dando lugar a un aumento del volumen de distribuci\u00f3n (vss7d = 0,92 1\/kg, vss21d = 0,95 i\/kg vss42d = 1,00 l\/kg) y del aclaramiento (cl7d = 0,08 i\/kg, cl21d = 0,097 l\/kg.H cl42d = 0,18 +- i\/kg.H), as\u00ed como a una disminuci\u00f3n de la permanencia del f\u00e1rmaco en el organismo (mrt7d = 11,86h, mrt21d = 9,36 h, mrt42d = 5,76 h).  el s\u00edndrome febril provocado por la administraci\u00f3n de endotoxina de escherichia coli produjo una disminuci\u00f3n del volumen de distribuci\u00f3n (vss = 0,72 i\/kg), as\u00ed como del aclaramiento (cl = 0,24 l\/kg.H) y un aumento de la permanencia en el organismo (mrt = 6,09 +- 1,45 h).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Comportamiento farmacocin\u00e9tico de la marbofloxacina en cabras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Comportamiento farmacocin\u00e9tico de la marbofloxacina en cabras <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Samanta Waxman Dova <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gasilda Rodr\u00edguez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Ballesteros moreno <\/li>\n<li>margarita Arboix arbo (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Miguel angel Bregante ucedo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Samanta Waxman Dova La marbofloxacina, un antimicrobiano del grupo de las fluoroquinolonas desarrollado exclusivamente para uso veterinario, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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