{"id":12252,"date":"2018-03-09T08:58:01","date_gmt":"2018-03-09T08:58:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-protea%c2%adna-quinasa-pak-skm1-y-de-la-gtpasa-cdc42-en-procesos-de-crecimiento-polarizado-en-saccharomyces-cerevisiae\/"},"modified":"2018-03-09T08:58:01","modified_gmt":"2018-03-09T08:58:01","slug":"implicacion-de-la-protea%c2%adna-quinasa-pak-skm1-y-de-la-gtpasa-cdc42-en-procesos-de-crecimiento-polarizado-en-saccharomyces-cerevisiae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/implicacion-de-la-protea%c2%adna-quinasa-pak-skm1-y-de-la-gtpasa-cdc42-en-procesos-de-crecimiento-polarizado-en-saccharomyces-cerevisiae\/","title":{"rendered":"Implicaci\u00f3n de la prote\u00edna quinasa pak skm1 y de la gtpasa cdc42 en procesos de crecimiento polarizado en saccharomyces cerevisiae."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodr\u00edguez Pach\u00f3n Jos\u00e9 M. <\/strong><\/h2>\n<p>Las prote\u00ednas pak ste20 y cla4 son efectores del agtpasa cdc42 implicados en el crecimiento polarizado en saccharmyces cerevisiae. Skm1, objeto de este estudio, es la tercera prote\u00edna pak de esta levadura. La sobreexpresi\u00f3n de skm1 y de su dominio quinasa conduce a fenotipos morfol\u00f3gicos similares a los obtenidos por la sobreexpresi\u00f3n de un alelo activado de cdc42. Ambas prote\u00ednas muestra, adem\u00e1s, interacci\u00f3n mediante el sistema de \u00abdos h\u00edbridos\u00bb.  la sobreexpresi\u00f3n de los dominios quinasas c-terminales de las prote\u00ednas pak conduce a la hiperfosforilaci\u00f3n de las map quinasas slt2, kss1 y fus3, lo que parece indicar una p\u00e9rdida en la especificidad de sustrato en estas prote\u00ednas cuando se las priva de su extremo n-terminal. Esta fosforilaci\u00f3n de la map quinasa slt2 no desaparece al eliminar la se\u00f1alizaci\u00f3n a trav\u00e9s de la ruta de feromonas, lo que parece indicar un cruce de rutas al nivel de la mapkkkk. La activaci\u00f3n de cdc42 por eliminaci\u00f3n de sus prote\u00ednas gap rgal1, rga2 y bem3 conduce tambi\u00e9n a la activaci\u00f3n de las tres map quinasas. El control de la actividad de slt2 por cdc42 depende de ste20 (no de skm1), ste7, y las map quinasas fus3 y kss1. La gtpasa rhol ejerce un papel modulador sobre la actividad de slt2, pero los efectos de cdc42 activo y la sobreexpresi\u00f3n de las prote\u00ednas pak truncadas sobre slt2 no dependen del rho1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la prote\u00edna quinasa pak skm1 y de la gtpasa cdc42 en procesos de crecimiento polarizado en saccharomyces cerevisiae.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la prote\u00edna quinasa pak skm1 y de la gtpasa cdc42 en procesos de crecimiento polarizado en saccharomyces cerevisiae. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodr\u00edguez Pach\u00f3n Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>C\u00e9sar Nombela Cano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Rotger anglada <\/li>\n<li>Jos\u00e9 P\u00e9rez mart\u00edn (vocal)<\/li>\n<li>Miguel Sanchez  perez (vocal)<\/li>\n<li> Maz\u00f3n calpe\u00f1a M\u00aa Jes\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodr\u00edguez Pach\u00f3n Jos\u00e9 M. Las prote\u00ednas pak ste20 y cla4 son efectores del agtpasa cdc42 implicados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,278],"tags":[3243,40098,40099,6618,6306,40097],"class_list":["post-12252","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-microbiologia","tag-cesar-nombela-cano","tag-jose-perez-martin","tag-mazon-calpena-ma-jesus","tag-miguel-sanchez-perez","tag-rafael-rotger-anglada","tag-rodriguez-pachon-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12252"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12252\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}