{"id":12302,"date":"2018-03-09T08:58:06","date_gmt":"2018-03-09T08:58:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-de-la-enzima-alfa-l-fucosidasa-serica-como-maracador-tumoral-en-cancer-colorrectal\/"},"modified":"2018-03-09T08:58:06","modified_gmt":"2018-03-09T08:58:06","slug":"valor-de-la-enzima-alfa-l-fucosidasa-serica-como-maracador-tumoral-en-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-de-la-enzima-alfa-l-fucosidasa-serica-como-maracador-tumoral-en-cancer-colorrectal\/","title":{"rendered":"Valor de la enzima alfa-l-fucosidasa s\u00e9rica como maracador tumoral en c\u00e1ncer colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Ayude Vazquez <\/strong><\/h2>\n<p>La enzima alfa-l-fucosidasa de humanos (alfa-l-fuc\u00f3sido fucohidrolasa, ec, 3.2.1.51) ha sido estudiada en individuos sanos y con diversas enfermedades, despertando un particular inter\u00e9s las alteraciones de sus niveles entejido y suero descritas en relaci\u00f3n con diversos procesos cancerosos. En estudios previos se ha econtrado una disminuci\u00f3n significativa de la actividad de la enzima-alfa-l-fucosidasa en el tejido tumoral con respecto a la mucosa sana de pacientes con c\u00e1ncer colorrectal, y se ha demostrado el valor pron\u00f3stico de dicha disminuci\u00f3n.  en este trabajo hemos demostrado que la actividad de la enzima alfa-l-fucosidasa de suero es significativamente inferior en pacientes con c\u00e1ncer colorrectal que en individuos sanos. Con ayuda de las curvas roc, hemos establecido como punto de corte en el diagn\u00f3stico del c\u00e1ncer colorrectal el valor de 5,6 u\/ml. Para completar el estudio hemos comparado la capacidad diagn\u00f3stica de la enzima alfa-l-fucosidasa con la del ant\u00edgeno carcinoembrionario, como marcador de uso establecido, y con la de un marcador en estudio, la glicoprote\u00edna cd26 soluble. El ant\u00edgeno carcinoembrionario estudiado en nuestros pacientes no muestra validez diagn\u00f3stica, como ha sido ampliamente descrito en otros trabajos. Por el contrario la glicoprote\u00edna cd 26 soluble pose\u00eda una eficiencia diagn\u00f3stica superior a la de la enzima, incluso para los estadios m\u00e1s tempranos del tumor. Tambi\u00e9n se analiz\u00f3 el valor diagn\u00f3stico del uso combinado de los tres marcadores tumorales.  no se han encontrado variaciones en los niveles de actividad de la enzima alfa-l-fucosidasa en funci\u00f3n del sexo o la edad del paciente, el tama\u00f1o, la localizaci\u00f3n anat\u00f3mica, el grado de diferenciaci\u00f3n o la capacidad invasiva del tumor. Sin embargo, s\u00ed hemos detectado una relaci\u00f3n entre los niveles de actividad de la enzima y el tipo de met\u00e1stasis. De este modo, la actividad media de la enzima alfa-l-fucosidasa fue m\u00e1s alta en paci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor de la enzima alfa-l-fucosidasa s\u00e9rica como maracador tumoral en c\u00e1ncer colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor de la enzima alfa-l-fucosidasa s\u00e9rica como maracador tumoral en c\u00e1ncer colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Ayude Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Paez De La Cadena Tortosa Mar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Jes\u00fas Vidal moreno <\/li>\n<li> Camacho Garc\u00eda angel tomas (vocal)<\/li>\n<li>mercedes Butron vila (vocal)<\/li>\n<li>estrella Pallas pallas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Ayude Vazquez La enzima alfa-l-fucosidasa de humanos (alfa-l-fuc\u00f3sido fucohidrolasa, ec, 3.2.1.51) ha sido estudiada en individuos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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