{"id":12307,"date":"2018-03-09T08:58:06","date_gmt":"2018-03-09T08:58:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-papel-de-las-metaloproteinasas-de-matriz-en-la-fase-aguda-del-ictus-isquemico\/"},"modified":"2018-03-09T08:58:06","modified_gmt":"2018-03-09T08:58:06","slug":"el-papel-de-las-metaloproteinasas-de-matriz-en-la-fase-aguda-del-ictus-isquemico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-papel-de-las-metaloproteinasas-de-matriz-en-la-fase-aguda-del-ictus-isquemico\/","title":{"rendered":"El papel de las metaloproteinasas de matriz en la fase aguda del ictus isqu\u00e9mico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Montaner Villalonga <\/strong><\/h2>\n<p>El ictus cardioemb\u00f3lico o embolia cerebral de origen card\u00edaco es la oclusi\u00f3n de una arteria cerebral por un \u00e9mbolo procedente del coraz\u00f3n. Con frecuencia origina infartos cerebrales de tama\u00f1o importante, presenta elevadas tasas de recanalizaci\u00f3n espont\u00e1nea y se asocia con transformaci\u00f3n hemorr\u00e1gica. todo ello, lo convierte en el subtipo de ictus humano m\u00e1s parecido al de los modelos animales de isquemia focal transitoria\/permanente.  las metaloproteinasas de la matriz (mmps) son una familia de enzimas proteol\u00edticas (zn-dependientes) que se encargan del remodelado de la matriz extracelular (mec) y que en conjunto pueden degradar todos los constituyentes de la misma.  entre las mmps, la gelatinasa a (mmp-2) y la gelatinasa b (mmp-9), que ser\u00e1n objeto de nuestro estudio, son capaces de digerir la l\u00e1mina basal endotelial, que juega un papel fundamental en el mantenimiento de la barrera hematoencef\u00e1lica.  en estudios de isquemia cerebral animal se ha demostrado el papel delet\u00e9reo de estas gelatinasas y c\u00f3mo su bloqueo farmacol\u00f3gico o las cepas knock out de mmp-9 muestran infartos cerebrales de menor tama\u00f1o. Sin embargo no existen estudios \u00abin vivo\u00bb en el ser humano que hayan analizado la expresi\u00f3n de estas mol\u00e9culas en el ictus isqu\u00e9mico.  por ello nuestros objetivos son determinar el perfil temporal de la expresi\u00f3n de mmps durante la fase aguda del ictus y relacionar los niveles plasm\u00e1ticos de estas mol\u00e9cular con la situaci\u00f3n neurol\u00f3gica de los pacientes, con su evoluci\u00f3n cl\u00ednica, con la duraci\u00f3n de la oclusi\u00f3n arterial y tama\u00f1o final de infarto asi como con la aparici\u00f3n de transformaci\u00f3n hemorr\u00e1gica en el seno del mismo. Estudiaremos tambi\u00e9n la relaci\u00f3n de estas mol\u00e9culas con otros marcadores neuroinflamatorios.  los resultados m\u00e1s relevantes de estos estudios son:  1,- hemos descrito por primera vez una sobreexpresi\u00f3n de mmp-9 en la fase aguda del ictus isqu\u00e9mico en humanos.  2,- los niveles<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El papel de las metaloproteinasas de matriz en la fase aguda del ictus isqu\u00e9mico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El papel de las metaloproteinasas de matriz en la fase aguda del ictus isqu\u00e9mico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Montaner Villalonga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 \u00e1lvarez Sab\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>vicent Fonollosa pla (vocal)<\/li>\n<li>Jos\u00e9 Castillo s\u00e1nchez (vocal)<\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Montaner Villalonga El ictus cardioemb\u00f3lico o embolia cerebral de origen card\u00edaco es la oclusi\u00f3n de una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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