{"id":12313,"date":"2018-03-09T08:58:06","date_gmt":"2018-03-09T08:58:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transformaciones-quimiozimaticas-en-los-estereoisomeros-del-anillo-a-de-la-1alfa-25-dihidroxivitamina-d3-sintesis-de-analogos-de-la-vitamina-d3-con-modificaciones-en-el-anillo-a\/"},"modified":"2018-03-09T08:58:06","modified_gmt":"2018-03-09T08:58:06","slug":"transformaciones-quimiozimaticas-en-los-estereoisomeros-del-anillo-a-de-la-1alfa-25-dihidroxivitamina-d3-sintesis-de-analogos-de-la-vitamina-d3-con-modificaciones-en-el-anillo-a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/transformaciones-quimiozimaticas-en-los-estereoisomeros-del-anillo-a-de-la-1alfa-25-dihidroxivitamina-d3-sintesis-de-analogos-de-la-vitamina-d3-con-modificaciones-en-el-anillo-a\/","title":{"rendered":"\u00abtransformaciones quimiozimaticas en los estereoisomeros del anillo a de la 1alfa, 25-dihidroxivitamina d3. sintesis de analogos de la vitamina d3 con modificaciones en el anillo a\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Gotor Fern\u00e1ndez <\/strong><\/h2>\n<p>En los ultimos a\u00f1os se ha producido un desarrollo espectacular en la investigacion de la vitamina d3 como consecuencia del papel que desempe\u00f1a su forma hormonalmente activa, la 1a, 25-dihidroxivitamina d3, en la diferenciacion celular, transcripcion genetica y su utilizacion como agente terapeutico en un amplio rango de enfermedades.  en esta memoria, estructurada en tres capitulos, se ha llevado a cabo la sintesis de analogos de la 1a-25-dihidroxivitamina d3 modificadas en su anillo a, asi como un estudio sobre la regioselectividad de los procesos enzimaticos de hidr\u00f3lisis y alcoxicarbonilaci\u00f3n de los correspondientes sintones precursores del anillo a.  en el primer capitulo se realiza un estudio cin\u00e9tico de la reaccion de hidr\u00f3lisis enzimatica selectiva de los cuatro esterois\u00f3meros diacetilados del anillo a, para lo cual se utilizaron distintas lipasas y esterasas como biocatalizadores. De esta manera, se preparan los derivados monoacetilados complementarios a los obtenidos mediante la reaccion de acilacion enzimatica, desarrollandose una sintesis quimioenzimatica muy eficaz de distintos precursores del anillo a. Ademas, se muestra una mejora en la preparaci\u00f3n de los isomeros cis del anillo a de la 1a 25-dihidroxivitamina d3. Parte de estos resultados estan recogidos en la publicaci\u00f3n:  cal-b catalyzed alkoxycarbonylation of a-ring stereosiomeric synthons of 1a,25-dihydroxyvitamin d3 and 1a,25-dhydroxy-19-nor-previtamin d3. A comparative study. First regioselective chemoenzymatic synthesis of 19-nor-a-ring carbonates. M.Diaz, v.Gotor-fernandez, m.Ferrero, s. Fernandez, v. Gotor, j.Org. Chem.2001,66,4227-4232.  en el segundo capitulo se describe la reaccion de alcoxicarbonilacion enzimatica de los precursores del anillo a con distintos carbonatos, catalizada por la lipasa de candida antarctica b. La proteccion selectiva de uno de los grupos hidroxilo permite la sintesis de analogos modificados, susceptibles a su vez de poste<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abtransformaciones quimiozimaticas en los estereoisomeros del anillo a de la 1alfa, 25-dihidroxivitamina d3. sintesis de analogos de la vitamina d3 con modificaciones en el anillo a\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abtransformaciones quimiozimaticas en los estereoisomeros del anillo a de la 1alfa, 25-dihidroxivitamina d3. sintesis de analogos de la vitamina d3 con modificaciones en el anillo a\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Gotor Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Gotor Santamar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Galindo brito <\/li>\n<li>Francisco Palacios gambra (vocal)<\/li>\n<li>joaquin Plumet ortega (vocal)<\/li>\n<li>pilar Goya leza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Gotor Fern\u00e1ndez En los ultimos a\u00f1os se ha producido un desarrollo espectacular en la investigacion de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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