{"id":12328,"date":"2018-03-09T08:58:08","date_gmt":"2018-03-09T08:58:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-multidisciplinar-sobre-la-reinervacion-tras-el-trasplante-cardiaco-y-su-repercusion-clinica\/"},"modified":"2018-03-09T08:58:08","modified_gmt":"2018-03-09T08:58:08","slug":"estudio-multidisciplinar-sobre-la-reinervacion-tras-el-trasplante-cardiaco-y-su-repercusion-clinica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-multidisciplinar-sobre-la-reinervacion-tras-el-trasplante-cardiaco-y-su-repercusion-clinica\/","title":{"rendered":"Estudio multidisciplinar sobre la reinervacion tras el trasplante cardiaco y su repercusion clinica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gallego Page Juan  Carlos <\/strong><\/h2>\n<p>Introduccion: el trasplante cardiaco (tc) conlleva la excisi\u00f3n del coraz\u00f3n enfermo y la implantaci\u00f3n del coraz\u00f3n donante que queda aislado del sistema nervioso aut\u00f3nomo del receptor, es decir funcionalmente denervado. Diversos estudios han mostrado evidencias de reinervaci\u00f3n (rn) del coraz\u00f3n trasplantado.  objetivos: estudiar la actividad nerviosa autonomica cardiaca tras el tc mediante tres tecnicas distintas: gammagrafia cardiaca (gg) con metayodo-beciluanidina-i123(mibg), analisis de la variabilidad de frecuencia cardiaca (vfc) y detecci\u00f3n de fibras nerviosas en muestras de biopsia endomioc\u00e1rdica (bem). Valorar la posible correlacion entre las distintas tecnicas, buscar posibles factores predictores de rn y analizar el efecto de la rn sobre el pronostico del paciente con tc.  pacientes y metodos: cincuenta y cinco pacientes con tc entre 0,5 y 160 meses antes del estudio (medio de 46 meses). Grupo control de 10 sujetos sanos. Realizaci\u00f3n de gammagrafia con mibg (marcador simpatico) con tecnica spect. Analisis de vfc en holter de 24 horas. Estudio de las muestras de bem mediante inmunohistoquimica con el anticuerpo anti-s100, para la detecci\u00f3n de fibras nerviosas.  resultados y conclusiones: los resultados obtenidos en la gg mostraron una actividad simp\u00e1tica muy inferior a la del grupo control, que aumentaba con el tiempo post-tc, aunque sin alcanzar valores normales. En el estudio spect se observo capatacion en el 31% de los pacientes, preferentemente en la region anteroseptal del ventriculo izquierdo. Existia  correlaci\u00f3n entre el parametro lf(marcador simpatico) de la vfc con los valores de la gg. El estudio inmunohistoquimico evidenci\u00f3 la existencia de fibras nerviosas en 36 pacientes (65,5%), los cuales presentaban mayor actividad parasimpatica en el an\u00e1lisis de vfc. El tiempo post-tc y la existencia de cirugia extracorporea previa, fueron predictores independientes para el desarrollo de rn. El analisis de las curva<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio multidisciplinar sobre la reinervacion tras el trasplante cardiaco y su repercusion clinica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio multidisciplinar sobre la reinervacion tras el trasplante cardiaco y su repercusion clinica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gallego Page Juan  Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Segovia Cubero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valent\u00edn Cuervas-mons mart\u00ednez <\/li>\n<li>raul Burgos lazaro (vocal)<\/li>\n<li>Carlos Saenz de la calzada campo (vocal)<\/li>\n<li> Crespo leiro M\u00aa Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gallego Page Juan Carlos Introduccion: el trasplante cardiaco (tc) conlleva la excisi\u00f3n del coraz\u00f3n enfermo y la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,141,10,139,156,1601],"tags":[25287,40344,40343,30221,15248,29649],"class_list":["post-12328","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-medicina-interna","category-patologia","category-patologia-cardiovascular","tag-carlos-saenz-de-la-calzada-campo","tag-crespo-leiro-ma-luisa","tag-gallego-page-juan-carlos","tag-javier-segovia-cubero","tag-raul-burgos-lazaro","tag-valentin-cuervas-mons-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12328","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12328"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12328\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}