{"id":123394,"date":"2025-02-08T09:17:19","date_gmt":"2025-02-08T09:17:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-biofarmaceutico-del-acido-pipemidico-en-formas-solidas-de-administracion-oral\/"},"modified":"2025-02-08T09:17:19","modified_gmt":"2025-02-08T09:17:19","slug":"estudio-biofarmaceutico-del-acido-pipemidico-en-formas-solidas-de-administracion-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-biofarmaceutico-del-acido-pipemidico-en-formas-solidas-de-administracion-oral\/","title":{"rendered":"Estudio biofarmaceutico del acido pipemidico en formas solidas de administracion oral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tamara Yates Karstegl <\/strong><\/h2>\n<p>Se estudia la influencia en la velocidad de disolucion ( in vitro ) y en la biodisponibilidad ( in vivo ) de diversas formas cristalinas obtenidas por recristalizacion en distintos medios y condiciones  a partir del acido pipemidico comercial. Para tipificar y diferenciar estas formas cristalinas desde el punto de vista fisico-quimico  se realizan ensayos tales como:  microscopia optica  espectroscopia i.R.  Termomicroscopia difraccion de rayos x  analisis termico diferencial y analisis termogravimetrico. Para observar el comportamiento  in vivo   se realiza un ensayo cruzado completo de dos de las formas  con ocho voluntarios sanos a los cuales se les administra una dosis de 400 mg de cada forma cristalina  por via oral en capsulas gelatinosas rigidas. Se determina la biodisponibilidad a partir de los datos obtenidos al estudiar elseguimiento de niveles en orina. Los valores se correlacionan con los obtenidos al realizar el estudio de velocidad de disolucion  in vitro  de las dos formas cristalinas  en agua destilada y en fluido intestinal artificial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio biofarmaceutico del acido pipemidico en formas solidas de administracion oral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio biofarmaceutico del acido pipemidico en formas solidas de administracion oral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tamara Yates Karstegl <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1987<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Cadorniga Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Lorenzo Fernandez <\/li>\n<li>Fermin Vazquez Lopez (vocal)<\/li>\n<li>Jos\u00e9 Celemi Pons (vocal)<\/li>\n<li>Alfonso Jes\u00fas Dominguez Gil Hurle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tamara Yates Karstegl Se estudia la influencia en la velocidad de disolucion ( in vitro ) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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