{"id":123557,"date":"2025-03-07T17:19:11","date_gmt":"2025-03-07T17:19:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-toxina-del-colera-sobre-la-adenilato-ciclasa-de-epitelio-intestinal-del-conejo\/"},"modified":"2025-03-07T17:19:11","modified_gmt":"2025-03-07T17:19:11","slug":"efecto-de-la-toxina-del-colera-sobre-la-adenilato-ciclasa-de-epitelio-intestinal-del-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-de-la-toxina-del-colera-sobre-la-adenilato-ciclasa-de-epitelio-intestinal-del-conejo\/","title":{"rendered":"Efecto de la toxina del colera sobre la adenilato ciclasa de epitelio intestinal del conejo ."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Dominguez Luengo <\/strong><\/h2>\n<p>En varios tipos celulares se ha demostrado que la toxinadel colera activa permanentemente a la adenilato ciclasa por adpribosilacion de la subunidad de su proteina gs. En los enterocitos  que son las celulas afectadas durante el desarrollo de la enfermedad del colera  la toxina se une a la membrana de microvilli mientras que la adenilato ciclasa esta localizada en la membrana basolateral. Ambas membranas estan funcionalmente separadas entre si por la union estrecha.  esta tesis se ha desarrollado con preparaciones de membranas intestinales purificadas en las que se ha estudiado la actividad adelinato ciclasa  la adpribosilacion  la union de gtp y la presencia de proteinas gs. Se ha demostrado la presencia de proteinas gs en la membrana de microvilli  en ausencia de subunidades cataliticas que estan presentes exclusivamente en la membrana basolateral. La toxina del colera actua directamente en la membrana de microvilli a la que se une  adpribosilando a las subunidades de las proteinas gs. Se propone que tras la accion de la toxina las subunidades se liberan al citosol y alcanzan  a traves de el la membrana basolateral  donde activan a la subunidad catalitica de la adenilato ciclasa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la toxina del colera sobre la adenilato ciclasa de epitelio intestinal del conejo .<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la toxina del colera sobre la adenilato ciclasa de epitelio intestinal del conejo . <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Dominguez Luengo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1987<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Sanchez Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Gascon Mu\u00f1oz <\/li>\n<li> De Andr\u00e9s Rodriguez-trelles  Fernando (vocal)<\/li>\n<li>Eladio Montoya Nelgar (vocal)<\/li>\n<li>Margarita Fern\u00e1ndez Mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Dominguez Luengo En varios tipos celulares se ha demostrado que la toxinadel colera activa permanentemente a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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