{"id":12431,"date":"2018-03-09T08:58:17","date_gmt":"2018-03-09T08:58:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-reelina-y-de-la-netrina-1-en-la-migracion-neuronal-en-el-sistema-nervioso-central-regulacion-por-hormonas-tiroiedeas\/"},"modified":"2018-03-09T08:58:17","modified_gmt":"2018-03-09T08:58:17","slug":"papel-de-la-reelina-y-de-la-netrina-1-en-la-migracion-neuronal-en-el-sistema-nervioso-central-regulacion-por-hormonas-tiroiedeas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-de-la-reelina-y-de-la-netrina-1-en-la-migracion-neuronal-en-el-sistema-nervioso-central-regulacion-por-hormonas-tiroiedeas\/","title":{"rendered":"Papel de la reelina y de la netrina-1 en la migraci\u00f3n neuronal en el sistema nervioso central. regulaci\u00f3n por hormonas tiroiedeas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Ruiz Grases <\/strong><\/h2>\n<p>El objetivo general de esta tesis ha sido profundizar en la funci\u00f3n de las mol\u00e9culas que hacen posible la migraci\u00f3n neuronal, permitiendo as\u00ed un correcto desarrollo del sistema nervioso central. Con este fin, nos hemos centrado en las mol\u00e9culas de gu\u00eda reelina y netrina-1, la prote\u00edna adaptadora dab1 y la hormona tiroidea, los mutantes de las cuales presentan graves alteraciones en el cerebro debidas a migraciones neuronales aberrantes en las primeras etapas del desarrollo.  concretamente hemos analizado el patr\u00f3n de expresi\u00f3n que presentan los tr\u00e1nscritos de reelina en el cerebro anterior del rat\u00f3n, desde estad\u00edos embrionarios tempranos hasta el adulto. Los an\u00e1lisis se han basado en la t\u00e9cnica de hibridaci\u00f3n in situ de elevada resoluci\u00f3n mediante una ribosonda contra reelina marcada con diogexigenina. Adem\u00e1s, mediante las t\u00e9cnicas de inmunomarcaje con anticuerpos contra distintos marcadores neuroqu\u00edmicos y la hibridaci\u00f3n in situ doble para detectar los tr\u00e1nscritos del enzima biosint\u00e9tico del gaba, hemos intentado caracterizar el tipo de neuronas que expresan reelina en rat\u00f3n.  en lo que se refiere a la expresi\u00f3n del gen reelina y dada la importancia de la hormona tiroidea en el desarrollo del cerebro, hemos investigado si esta hormona podr\u00eda estar regulando la expressi\u00f3n de reelina. Disponemos de un modelo experimental en rata que reproduce los efectos de hipotiroidismo y hemos analizado un estudio comparativo entre ratas hipotiroideas y control en las cuales hemos analizado los patrones de expressi\u00f3n de los tr\u00e1nscritos de reelina y de la prote\u00edna reelina. Adem\u00e1s, dado que la acci\u00f3n intracelular de reelina est\u00e1 mediatizada por la prote\u00edna se ven alterados en los animales hiporitorideos. Finalmente, y con la finalidad de estudiar directamente si la hormona tiroidea es capaz de reestablecer el patr\u00f3n normal de expressi\u00f3n de reelina en los animales hipotiroiedeos, hemos realizado experimentos in vitro y i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la reelina y de la netrina-1 en la migraci\u00f3n neuronal en el sistema nervioso central. regulaci\u00f3n por hormonas tiroiedeas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la reelina y de la netrina-1 en la migraci\u00f3n neuronal en el sistema nervioso central. regulaci\u00f3n por hormonas tiroiedeas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Ruiz Grases <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Soriano Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: merce Durfort coll <\/li>\n<li>joan m.v. Blasi cab\u00fas (vocal)<\/li>\n<li>Carlos L\u00f3pez Garc\u00eda (vocal)<\/li>\n<li>Fernando De castro soubriet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Ruiz Grases El objetivo general de esta tesis ha sido profundizar en la funci\u00f3n de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,35],"tags":[19461,24803,33123,20203,14022,40653],"class_list":["post-12431","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-ciencias-de-la-vida","tag-carlos-lopez-garcia","tag-eduardo-soriano-garcia","tag-fernando-de-castro-soubriet","tag-joan-m-v-blasi-cabus","tag-merce-durfort-coll","tag-monica-ruiz-grases"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12431"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12431\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}