{"id":12432,"date":"2018-03-09T08:58:17","date_gmt":"2018-03-09T08:58:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-monocinas-en-el-higado-y-rinon-de-cerdos-inoculados-con-el-virus-de-la-peste-porcina-africana\/"},"modified":"2018-03-09T08:58:17","modified_gmt":"2018-03-09T08:58:17","slug":"expresion-de-monocinas-en-el-higado-y-rinon-de-cerdos-inoculados-con-el-virus-de-la-peste-porcina-africana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/expresion-de-monocinas-en-el-higado-y-rinon-de-cerdos-inoculados-con-el-virus-de-la-peste-porcina-africana\/","title":{"rendered":"Expresion de monocinas en el higado y ri\u00f1on de cerdos inoculados con el virus de la peste porcina africana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tigest Mekonnen Seyoum <\/strong><\/h2>\n<p>Con el objetivo de determinar la relaci\u00f3n entre las lesiones hep\u00e1ticas y renales en la ppa y la producci\u00f3n de monocinas, se inocularon 21 cerdos con una dosis de 5 x 10 5 had 50 del aislado espa\u00f1a 70 del virus de la ppa, aislado clasificado como virulento, por v\u00eda intramuscular. 3 animales de similares caracter\u00edsticas fueron utilizados como control negativo. Previamente al sacrificio se procedi\u00f3 a la toma de sangre para realizar el recuento de leucocitos, formula leucitaria y estudio serol\u00f3gico de monocinas. En la necropsia, y tras el estudio anatomopatol\u00f3gico, se tomaron muestras de h\u00edgado y ri\u00f1\u00f3n que fueron fijadas en diferentes fijadores qu\u00edmicos para el estudio estructural, inmunohistoqu\u00edmico y ultraestructural.  la lesi\u00f3n hep\u00e1tica se caracteriz\u00f3 por un ligero infiltrado portal, incremento en el n\u00famero de c\u00e9lulas circulantes, hiperplasia e hipetrofila de las c\u00e9lulas de kupffer y, desde los 5 dpi, microtrombosis, necrosis y hemorragias, con formaci\u00f3n de lagunas hem\u00e1ticas. En el infiltrado y en las c\u00e9lulas circulantes se observaron dos tipos de muerte celular: los monocitos y macr\u00f3fagos con replicaci\u00f3n v\u00edrica mostraban signos de necrosis, mientras que los linfocitos sufr\u00edan muerte celular por apoptosis. La infecci\u00f3n y replicaci\u00f3n del virus en el higado es detectada desde los 3 dpi en monocitos-macr\u00f3fagos, afectando a hepatocitos y c\u00e9lulas de localizaci\u00f3n perisinusoidal en fechas posteriores.  la lesi\u00f3n renal consisti\u00f3 en edema, microhermorragias y microtrombosis, asociados a la activaci\u00f3n fagoc\u00edtica de las c\u00e9lulas endoteliales que originaba la exposici\u00f3n del col\u00e1geno subedotelial y permit\u00eda la salida de c\u00e9lulas circulantes al intersticio. Aunque leve, existe una glomerulonefritis proliferativa en la fase final del experimento. Las c\u00e9lulas infectadas, adem\u00e1s de monocitos y macr\u00f3fagos desde los 5 dpi en gran n\u00faemro, fueron c\u00e9lulas epiteliales de los t\u00fabulos renales, fibroblastos, c\u00e9lulas endo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de monocinas en el higado y ri\u00f1on de cerdos inoculados con el virus de la peste porcina africana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de monocinas en el higado y ri\u00f1on de cerdos inoculados con el virus de la peste porcina africana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tigest Mekonnen Seyoum <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Gomez Villamandos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amador Jover moyano <\/li>\n<li>Jos\u00e9 Hervas rodriguez (vocal)<\/li>\n<li>Francisco j. Salguero bodes (vocal)<\/li>\n<li>eduardo Ruiz villamor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tigest Mekonnen Seyoum Con el objetivo de determinar la relaci\u00f3n entre las lesiones hep\u00e1ticas y renales en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,973,20868,495,2014,1946,3030],"tags":[533,40658,40657,40655,40656,40654],"class_list":["post-12432","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-cordoba","category-inmunologia-veterinaria","category-patologia-veterinaria","category-porcinos","category-produccion-animal","category-virologia-veterinaria","tag-amador-jover-moyano","tag-eduardo-ruiz-villamor","tag-francisco-j-salguero-bodes","tag-jose-carlos-gomez-villamandos","tag-jose-hervas-rodriguez","tag-tigest-mekonnen-seyoum"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12432"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12432\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}