{"id":12456,"date":"2018-03-09T08:58:19","date_gmt":"2018-03-09T08:58:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacologa%c2%ada-cla%c2%adnica-de-la-metileno-dioximetanfetamina-mdma-extasis-tras-su-adminsitracion-a-dosis-repetidas\/"},"modified":"2018-03-09T08:58:19","modified_gmt":"2018-03-09T08:58:19","slug":"farmacologa%c2%ada-cla%c2%adnica-de-la-metileno-dioximetanfetamina-mdma-extasis-tras-su-adminsitracion-a-dosis-repetidas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacologa%c2%ada-cla%c2%adnica-de-la-metileno-dioximetanfetamina-mdma-extasis-tras-su-adminsitracion-a-dosis-repetidas\/","title":{"rendered":"Farmacolog\u00eda cl\u00ednica de la metileno dioximetanfetamina (mdma, extasis) tras su adminsitraci\u00f3n a dosis repetidas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngels Tomillero Alemandy <\/strong><\/h2>\n<p>El objetivo de esta tesis fue conocer la farmacolog\u00eda de la mdma tras la administraci\u00f3n de dos dosis consecutivas separadas por un intervalo de cuatro horas, profundizando especialmente en su farmacocin\u00e9tica y en la posible aparici\u00f3n de fen\u00f3menos de tolerancia aguda o sensibilidad que pueden favorecer la presentaci\u00f3n de toxicidad. Se dise\u00f1o un ensayo cl\u00ednico a doble ciego, cruzado, controlado con placebo, en el que participaron ocho voluntarios sanos consumidores habituales de mdam. Cada suejto paricip\u00f3 en cuatro sesiones separadas por una semana de per\u00edodo de blanqueo. Tras la administraci\u00f3n reptida se observaron frecuencia card\u00edaca y la temperatura respecto a la dosis \u00fanica. Estos aumentos no alcanzaron los esperables por el principio de superposici\u00f3n. El rendimiento psicomotor y la tensi\u00f3n muscular mostraron incrementos mayores que la dosis \u00fanica en las escalas de euforia, estimulaci\u00f3n, efectos desagradables y cambios en las percepciones. no se presentaron alucinaciones ni alteraciones psic\u00f3ticas. La concentraci\u00f3n plasm\u00e1tica de mdam tras la administraci\u00f3n repetida super\u00f3 en un 20% la eperable por la suma simple de las dos dosis administradas, present\u00e1ndose una clara tolerancia en todas las variables estudiadas excepto para la tensi\u00f3n muscular y el rendimiento psicomotor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacolog\u00eda cl\u00ednica de la metileno dioximetanfetamina (mdma, extasis) tras su adminsitraci\u00f3n a dosis repetidas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacolog\u00eda cl\u00ednica de la metileno dioximetanfetamina (mdma, extasis) tras su adminsitraci\u00f3n a dosis repetidas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngels Tomillero Alemandy <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mag\u00ed Farr\u00e9 Albaladejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: frances\u00ed\u00a7 Jan\u00e9 carren\u00ed\u00a7a <\/li>\n<li>ram\u00f3n Miralles (vocal)<\/li>\n<li>jordi Cami morell (vocal)<\/li>\n<li>Marta Torrens melich (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngels Tomillero Alemandy El objetivo de esta tesis fue conocer la farmacolog\u00eda de la mdma tras la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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