{"id":12489,"date":"2018-03-09T08:58:21","date_gmt":"2018-03-09T08:58:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-regiones-de-la-protea%c2%adna-f-implicadas-en-el-proceso-de-fusion-de-membranas-mediada-por-la-protea%c2%adna-de-fusion-del-virus-de-la-enfermedad-de-newcastle\/"},"modified":"2018-03-09T08:58:21","modified_gmt":"2018-03-09T08:58:21","slug":"estudio-de-las-regiones-de-la-protea%c2%adna-f-implicadas-en-el-proceso-de-fusion-de-membranas-mediada-por-la-protea%c2%adna-de-fusion-del-virus-de-la-enfermedad-de-newcastle","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-las-regiones-de-la-protea%c2%adna-f-implicadas-en-el-proceso-de-fusion-de-membranas-mediada-por-la-protea%c2%adna-de-fusion-del-virus-de-la-enfermedad-de-newcastle\/","title":{"rendered":"Estudio de las regiones de la prote\u00edna f implicadas en el proceso de fusi\u00f3n de membranas mediada por la prote\u00edna de fusi\u00f3n del virus de la enfermedad de newcastle"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  San Roman Sarmiento Kathie Jessica <\/strong><\/h2>\n<p>El virus de la enfermedad de newcastle (ndv) es un paramixovirus que afecta al sistema respiratorio y\/o nervioso de aves de corral. Este virus tiene una membrana lipoproteica que contiene dos glicoproteinas transmembranales, la hemaglutinina-neuraminidasa (hn) y la prote\u00edna de fusi\u00f3n (f). La hn es la responsable de la uni\u00f3n del virus a los receptores celulares. La prote\u00edna f contiene el p\u00e9ptido de fusi\u00f3n responsable directo de la fusi\u00f3n de la membrana v\u00edrica y celular, y tres regiones llamadas \u00abheptad repeats\u00bb que se supone participan tambi\u00e9n en el proceso de fusi\u00f3n de membranas. para profundizar en el estudio de la fusi\u00f3n de membranas inducida por el ndv hemos estudiado la actividad biol\u00f3gica y algunas propiedades funcionales de dos p\u00e9ptidos sint\u00e9ticos, n24 y c24, derivados de las regiones hr1 y hr2 de la prote\u00edna f. Ambos p\u00e9ptidos han resultado ser inhibidores de la fusi\u00f3n, mostrando diferente potencia inhibitoria sobre la infecci\u00f3n del ndv en cultivos celulares. As\u00ed, el p\u00e9ptido n24 result\u00f3 ser 150 veces m\u00e1s potente que el p\u00e9ptido c24. Ambos p\u00e9ptidos interact\u00faan entre s\u00ed, y cuando se mezclan en concentraciones equimolares se anula su efecto inhibidor de la fusi\u00f3n. Adem\u00e1s, los p\u00e9ptidos inducen la agregaci\u00f3n de ves\u00edculas fosfolip\u00eddcas neutras y ani\u00f3nicas, aunque carecen de propiedades fusog\u00e9nicas. Por ello, proponemos que su efecto inhibidor de la fusi\u00f3n se deba a qu\u00e9 interaccionan con regiones funcionales de la prote\u00edna de fusi\u00f3n, probablemente con las regiones hr complementaria, impidiendo que la prote\u00edna f adquiera su conformaci\u00f3n fusog\u00e9nica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las regiones de la prote\u00edna f implicadas en el proceso de fusi\u00f3n de membranas mediada por la prote\u00edna de fusi\u00f3n del virus de la enfermedad de newcastle<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las regiones de la prote\u00edna f implicadas en el proceso de fusi\u00f3n de membranas mediada por la prote\u00edna de fusi\u00f3n del virus de la enfermedad de newcastle <\/li>\n<li><strong>Autor:<\/strong>\u00a0  San Roman Sarmiento Kathie Jessica <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Villar Ledesma<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m. paz Battaner arias <\/li>\n<li>Francisco Jos\u00e9 Aranda Martinez (vocal)<\/li>\n<li>julio Coll mirales (vocal)<\/li>\n<li>Mar\u00eda  amparo Estepa perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de San Roman Sarmiento Kathie Jessica El virus de la enfermedad de newcastle (ndv) es un paramixovirus que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,36606,35,9386],"tags":[9540,25176,40824,19749,40825,40823],"class_list":["post-12489","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-ciencias-de-la-vida","category-salamanca","tag-enrique-villar-ledesma","tag-francisco-jose-aranda-Martinez","tag-julio-coll-mirales","tag-m-paz-battaner-arias","tag-maria-amparo-estepa-perez","tag-san-roman-sarmiento-kathie-jessica"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12489"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12489\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}