{"id":12504,"date":"2018-03-09T08:58:22","date_gmt":"2018-03-09T08:58:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-aportaciones-a-la-caracterizacion-genota%c2%adpica-del-cancer-de-mama\/"},"modified":"2018-03-09T08:58:22","modified_gmt":"2018-03-09T08:58:22","slug":"nuevas-aportaciones-a-la-caracterizacion-genota%c2%adpica-del-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevas-aportaciones-a-la-caracterizacion-genota%c2%adpica-del-cancer-de-mama\/","title":{"rendered":"Nuevas aportaciones a la caracterizaci\u00f3n genot\u00edpica del c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Salazar Saez <\/strong><\/h2>\n<p>El c\u00e1ncer de mama como el resto de los tumores es una enfermedad gen\u00e9tica en que las c\u00e9lulas tumorales crecen de forma an\u00f3mala, invaden los tejidos y metastatizan a distancia. Uno de los genes implicados en el fenotipo tumoral del c\u00e1ncer de mama es el gen p53.  hemos estudiado las mutaciones de p53 en tumores de mama en mujeres de nuestra poblaci\u00f3n encontrando un 16% de mutaciones, la mayor parte se encuentran en secuencias consideradas como \u00abpuntos calientes\u00bb del gen.  en los \u00faltimos a\u00f1os se han estudiado los genes que codifican enzimas metabolizadoras de sustancias carcin\u00f3genas ya que se cree que los individuos con alteraciones enzim\u00e1ticas tendr\u00edan m\u00e1s riesgo de desarrollar mutaciones en el dna y por tanto tumores.  hemos analizado los genes que codifican los enzimas cyp2d6, gstt1, gstm1 y gstp1 comparando los genotipos de mujeres con c\u00e1ncer de mama y poblaci\u00f3n control sana. A1 analizar los resultados obtenidos, consideramos que el genotipo nulo de gstm1 en el subgrupo de pacientes postmenop\u00e1usicas, genotipos homocigoto pobre metabolizador del gen cyp2d6 y el genotipo valina\/valina de gen gstp1 podr\u00edan estar asociados a un mayor riesgo de desarrollar c\u00e1ncer de mama en nuestra poblaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas aportaciones a la caracterizaci\u00f3n genot\u00edpica del c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas aportaciones a la caracterizaci\u00f3n genot\u00edpica del c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Salazar Saez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li>cristina Miner pinu (vocal)<\/li>\n<li>eduardo D\u00edaz-rubio Garc\u00eda (vocal)<\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Salazar Saez El c\u00e1ncer de mama como el resto de los tumores es una enfermedad gen\u00e9tica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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