{"id":12524,"date":"2018-03-09T08:58:24","date_gmt":"2018-03-09T08:58:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-herramientas-para-el-modelado-y-la-simulacion-de-rutas-metabolicas\/"},"modified":"2018-03-09T08:58:24","modified_gmt":"2018-03-09T08:58:24","slug":"desarrollo-de-herramientas-para-el-modelado-y-la-simulacion-de-rutas-metabolicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/desarrollo-de-herramientas-para-el-modelado-y-la-simulacion-de-rutas-metabolicas\/","title":{"rendered":"Desarrollo de herramientas para el modelado y la simulaci\u00f3n de rutas metabolicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Ram\u00f3n De Atauri Carulla <\/strong><\/h2>\n<p>Esta tesis doctoral est\u00e1 dedicada al desarrollo de herramientas matem\u00e1ticas e inform\u00e1ticas para el an\u00e1lisis de v\u00edas metab\u00f3licas en estado estacionario, especialmente mediante coeficientes de sensibilidad, dentro de los entornos de an\u00e1lisis de la teor\u00eda de sistemas bioqu\u00edmicos (biochemical systems theory, bst) y del an\u00e1lisis del control metab\u00f3lico (metabolic control an\u00e1lisis, mca). Los cap\u00edtulos que la componen se estructura en tres partes. La primera parte se preocupa de aspectos derivados del tipo de representaci\u00f3n matem\u00e1ticas que es usado para describir v\u00edas metab\u00f3licas. En el primer cap\u00edtulo se estudia un tipo de representaci\u00f3n llamado s-systems, dentro de la bst, donde los procesos cin\u00e9ticos aparecen agregados en procesos globales de s\u00edntesis y de degradaci\u00f3n. En este primer cap\u00edtulo se desarrollan herramientas espec\u00edficas encaminadas a predecir cual va a ser el grado de violaci\u00f3n de la estequiometr\u00eda que se comete al solucionar estados estacionarios en un s-system.  por otro lado al representar matem\u00e1ticamente una v\u00eda metab\u00f3lica, esta aparece como un segmento del metabolismo que se analiza como una entidad aislada, de modo que intermediarios que ser\u00edan variables dependientes si consider\u00e1semos todo el metabolismo, pasan a ser considerados par\u00e1metros de valor fijo, y determinan los l\u00edmites del modelo.  en los cap\u00edtulos ii y iii se analizan la dependencia de los coeficientes de sensibilidad a estos l\u00edmites.  en el cap\u00edtulo ii se estudia, por una parte, el efecto que la incertidumbre en los valores que se asigna a estos par\u00e1metros puede tener a la hora de caracterizar el comportamiento del modelo mediante sensibilidades y, por otra parte, se estudia la utilidad de las sensibilidades de segundo orden para evaluar estas situaciones.  en el cap\u00edtulo iii se analiza, en los coeficientes de sensibilidad, el efecto que comporta el extender una v\u00eda metab\u00f3lica lineal agregando una etapa extra de entrada<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de herramientas para el modelado y la simulaci\u00f3n de rutas metabolicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de herramientas para el modelado y la simulaci\u00f3n de rutas metabolicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Ram\u00f3n De Atauri Carulla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Cascante Serratosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enric Canela campos <\/li>\n<li> Lupia\u00f1ez cara Jos\u00e9 Antonio (vocal)<\/li>\n<li>Jos\u00e9 Carreras barn\u00e9s (vocal)<\/li>\n<li>francesc Sagues mestre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Ram\u00f3n De Atauri Carulla Esta tesis doctoral est\u00e1 dedicada al desarrollo de herramientas matem\u00e1ticas e inform\u00e1ticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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