{"id":125265,"date":"2025-12-18T19:29:53","date_gmt":"2025-12-18T19:29:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunoquimico-de-una-paraproteina-biclonal-igm\/"},"modified":"2025-12-18T19:29:53","modified_gmt":"2025-12-18T19:29:53","slug":"estudio-inmunoquimico-de-una-paraproteina-biclonal-igm","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-inmunoquimico-de-una-paraproteina-biclonal-igm\/","title":{"rendered":"Estudio inmunoquimico de una paraproteina biclonal igm"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Garc\u00eda Gonz\u00e1lez <\/strong><\/h2>\n<p>Se estudia desde un punto de vista inmunoquimico  dos paraproteinas igm detectadas en el suero de un paciente afecto de macroglobulinemia de waldestrom. Ambas inmunoglobulinas fueron clasificadas como igm han 1 lambda e igm han 2  kappa. Los dominios variables de las cadenas pesadas han y 1 han 2 pertenecian al subgrupo de variabilidad vhiii. Las cadenas ligeras de ambas inmunoglobulinas  estaban glicosiladas  lo que les conferia un peso molecular anormalmente elevado. Los estudios idiotipicos mostraton una identidad parcial de ambas inmunoglobulinas  las cuales comparten determinantes antigenicos comunes  como se deduce por analisis doble difusion  radio inmunoanalisis competitivo y tecnicas de western blot utilizando antisueros antiidiotipo especificos. Todos los datos  apoyan la hipotesis de que los clones celulares que sintetizan ambas inmunoglobulinas  derivan de un ancestro celular comun  relativamente cercano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunoquimico de una paraproteina biclonal igm<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunoquimico de una paraproteina biclonal igm <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Garc\u00eda Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1987<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fernandez Diaz Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez Zabalza (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Macarulla Greoles (vocal)<\/li>\n<li>Alfonso Sanchez Ibarrola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Garc\u00eda Gonz\u00e1lez Se estudia desde un punto de vista inmunoquimico dos paraproteinas igm detectadas en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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