{"id":12553,"date":"2018-03-09T08:58:26","date_gmt":"2018-03-09T08:58:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-la-topologia-molecular-y-la-qua%c2%admica-combinatoria-virtual-para-la-busqueda-de-nuevos-compuestos-con-actividad-antihistaminica-seleccion-sintesis-y-ensayos\/"},"modified":"2018-03-09T08:58:26","modified_gmt":"2018-03-09T08:58:26","slug":"aplicacion-de-la-topologia-molecular-y-la-qua%c2%admica-combinatoria-virtual-para-la-busqueda-de-nuevos-compuestos-con-actividad-antihistaminica-seleccion-sintesis-y-ensayos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-de-la-topologia-molecular-y-la-qua%c2%admica-combinatoria-virtual-para-la-busqueda-de-nuevos-compuestos-con-actividad-antihistaminica-seleccion-sintesis-y-ensayos\/","title":{"rendered":"Aplicaci\u00f3n de la topolog\u00eda molecular y la qu\u00edmica combinatoria virtual para la busqueda de nuevos compuestos con actividad antihistaminica. selecci\u00f3n, sintesis y ensayos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Jos\u00e9 Duart Duart <\/strong><\/h2>\n<p>Se ha aplicado la topolog\u00eda molecular al grupo terapeutico de los antihistaminicos, obteni\u00e9ndose funciones de predicci\u00f3n de propiedades farmacodin\u00e1micas, farmacocin\u00e9ticas y fisicoqu\u00edmicas avaladas por loa estudios de estabilidad y aleatroiedad realizados, que junto con las funciones discriminantes obtenidas se ha establecido un modelo matem\u00e1tico-topol\u00f3gico capaz de clasificar de una manera te\u00f3rica a un compuesto por su actividad antihistam\u00ednica.  una vez seleccionados los compuestos con te\u00f3rica actividad, se les ha aplicado un modelo metem\u00e1tico-topol\u00f3gico de toxicidad, en funci\u00f3n de su posible actividad como carcinog\u00e9ncio y por el efecto sedante que puedan presentar.  los compuestos finalmente seleccionados lo han sido por cumplir ambos modelos y tras la aplicaci\u00f3n de los mismso a bases de datos (de donde se han seleccionado dos) y por la utilizaci\u00f3n de la qu\u00edmica combinatoria virtual selecionandose otros dos. Con el fin de poner de manifiesto la actividad faramcol\u00f3gica deseada se han realizado los ensayos farmacol\u00f3gicos propuestos por watanbe et al., Obteni\u00e9ndose que los compuestos seleccionados presentan todos ellos la actividad anthihistaminica buscada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de la topolog\u00eda molecular y la qu\u00edmica combinatoria virtual para la busqueda de nuevos compuestos con actividad antihistaminica. selecci\u00f3n, sintesis y ensayos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de la topolog\u00eda molecular y la qu\u00edmica combinatoria virtual para la busqueda de nuevos compuestos con actividad antihistaminica. selecci\u00f3n, sintesis y ensayos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Jos\u00e9 Duart Duart <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Anton Fos Gerardo M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Moreno frigols <\/li>\n<li>ernesto Estrada roger (vocal)<\/li>\n<li>Jos\u00e9 Mart\u00ednez calatayd (vocal)<\/li>\n<li>Miguel \u00e1ngel Miranda alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jos\u00e9 Duart Duart Se ha aplicado la topolog\u00eda molecular al grupo terapeutico de los antihistaminicos, obteni\u00e9ndose [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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