{"id":12554,"date":"2018-03-09T08:58:27","date_gmt":"2018-03-09T08:58:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/esclarecimiento-del-mecanismo-de-accion-de-la-dotarizina-como-agente-antimigranoso\/"},"modified":"2018-03-09T08:58:27","modified_gmt":"2018-03-09T08:58:27","slug":"esclarecimiento-del-mecanismo-de-accion-de-la-dotarizina-como-agente-antimigranoso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/esclarecimiento-del-mecanismo-de-accion-de-la-dotarizina-como-agente-antimigranoso\/","title":{"rendered":"Esclarecimiento del mecanismo de acci\u00f3n de la dotarizina como agente antimigra\u00f1oso"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Ru\u00edz Nu\u00f1o <\/strong><\/h2>\n<p>El objetivo principal de la presente tesis doctoral ha sido profundizar en los posibles mecanismos de acci\u00f3n de la dotarizina que puedan justificar su uso como agente preventivo de la crisis de migra\u00f1a, bas\u00e1ndonos en los datos previos que sugieren su posible utilidad cl\u00ednica en esta indicaci\u00f3n. para ello, nos planteamos los siguientes objetivos:  1,- caracterizar la posible selectividad de la dotarizina sobre la contractilidad de distintos lechos vasculares inducida por distintos agentes vasoactivos.  2,- caracterizar los efectos de la dotarizina en los canales neuronales de ca2+ del subtipo p\/q, utiliz\u00e1ndose como modelo neuronal las c\u00e9lulas cromafines bovinas.  3,- caracterizar los efectos de la dotarizina sobre la liberaci\u00f3n de neurotransmisores mediada por canales de ca2+ del subtipo p\/q.  as\u00ed, por medio de distintas t\u00e9cnicas de reactividad vascular como ba\u00f1o de \u00f3rganos y el mi\u00f3grafo de mulvany, la t\u00e9cnica electrofisiol\u00f3gica de \u00abpatch-clamp\u00bb, medida de la secreci\u00f3n de catecolaminas en c\u00e9lulas cromafines bovinas y medida de la liberaci\u00f3n de, (3h)na en neuronas simp\u00e1ticas de rata, se obtuvieron las siguientes conclusiones:  * la dotarizina bloquea de forma selectiva la contracci\u00f3n evocada por 5-ht em distintos lechos vasculares tanto a nivel perif\u00e9rico como cerebral mediante un mecanismo dual: bloqueo serotonin\u00e9rgico y bloqueo de canales de calcio.  * la dotarizina bloquea en forma no competitiva los receptores 5-ht.  * el efecto calcio-antagonista de la dotarizina no muestra propiedades de votlaje-dependencia.  * la dotarizina bloquea la contracci\u00f3n evocada por estimulaci\u00f3n el\u00e9ctrica de campo, probablemente por bloquear la liberaci\u00f3n de na desde terminaciones nerviosas.  * la dotarizina bloquea las corrientes globales de ca2+ en forma concentraci\u00f3n-, voltaje y uso-dependiente.  * la dotarizina favorece la inactivaci\u00f3n del canal p\/q.  * la dotarizina bloquea la liberaci\u00f3n de (3h)na en neuronas si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Esclarecimiento del mecanismo de acci\u00f3n de la dotarizina como agente antimigra\u00f1oso<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Esclarecimiento del mecanismo de acci\u00f3n de la dotarizina como agente antimigra\u00f1oso <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Ru\u00edz Nu\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Gand\u00eda Juan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>mercedes Solares s\u00e1nchez (vocal)<\/li>\n<li>Antonio Rodr\u00edguez artalejo (vocal)<\/li>\n<li>Mar\u00eda   teresa Tejerina sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Ru\u00edz Nu\u00f1o El objetivo principal de la presente tesis doctoral ha sido profundizar en los posibles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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