{"id":12557,"date":"2018-03-09T08:58:27","date_gmt":"2018-03-09T08:58:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/los-polimorfismos-del-gen-del-pai-1-modulan-los-cambios-inducidos-por-la-alimentacion-sobre-dicha-proteina\/"},"modified":"2018-03-09T08:58:27","modified_gmt":"2018-03-09T08:58:27","slug":"los-polimorfismos-del-gen-del-pai-1-modulan-los-cambios-inducidos-por-la-alimentacion-sobre-dicha-proteina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/los-polimorfismos-del-gen-del-pai-1-modulan-los-cambios-inducidos-por-la-alimentacion-sobre-dicha-proteina\/","title":{"rendered":"Los polimorfismos del gen del pai-1 modulan los cambios inducidos por la alimentaci\u00f3n sobre dicha proteina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Dolores Adarraga Cansino <\/strong><\/h2>\n<p>Introduccion  el pai-1 es el principal modulador de la fibrinolisis por su acci\u00f3n inhibitoria sobre el activador tisular del plasmin\u00f3geno del pai-1. La insulina, entre otros factores como la alimentaci\u00f3n y los polimorfismos del gen que lo codifica, puede influir en su concentraci\u00f3n plasm\u00e1tica.  hip\u00f3tesis de trabajo  demostrar que las cifras plasm\u00e1ticas de pai-1 est\u00e1n determinadas por la existencia de una interacci\u00f3n entre los factores gen\u00e9ticos y la alimentaci\u00f3n.  objetivos  estudiar si los niveles plasm\u00e1ticos de pai-1 resultan de la interacci\u00f3n entre el polimorfismo 4g\/5g y el tipo de alimentaci\u00f3n, analizando el comportamiento de los poradores de los distintos genotipos tras una alimentaci\u00f3n rica en grasa saturada, otra rica en hidratos de carbono y otra tipo mediterr\u00e1nea. investigar si la respuesta del pai-1  a la alimentaci\u00f3n depende de la influencia de \u00e9sta sobre la resistencia perif\u00e9rica a la insulina. Explorar la interacci\u00f3n entre la alimentaci\u00f3n  mediterr\u00e1nea y la rica en hidratos de carbono con el polimorfismo a\/g en la posici\u00f3n 844 de la regi\u00f3n promotora del gen que codifica el pai-1.  personas, dise\u00f1o y metodolog\u00eda  se seleccionaron 59 voluntarios sanos, 30 hombres y 29 mujeres, seg\u00fan las variaciones de actividad del pai-1 en funci\u00f3n del polimorfismo 4g5g de la regi\u00f3n promotora del gen que codifica esta prote\u00edna. Todos recibieron una alimentaci\u00f3n de estabilizaci\u00f3n de cuatro semanas rica en grasa saturada y tras \u00e9sta se administr\u00f3, de forma aleatroziada y cruzada, una alimentaci\u00f3n t\u00edpica mediterr\u00e1nea rica en gasa monoinsaturada y otra pobre en grasa, y rica en hidratos de carbono. Al final de cada periodo de determinaron los l\u00edpidos plasm\u00e1ticos, la actividad del pai-1, el pai-1 antig\u00e9nico y se obtuvo la respuesta perif\u00e9rica a la acci\u00f3n de la insulina mediante el test de supresi\u00f3n de insulina con somastostatina.  resultados y conclusiones  las cifras de glucosa media y las de p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Los polimorfismos del gen del pai-1 modulan los cambios inducidos por la alimentaci\u00f3n sobre dicha proteina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Los polimorfismos del gen del pai-1 modulan los cambios inducidos por la alimentaci\u00f3n sobre dicha proteina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Dolores Adarraga Cansino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez <\/li>\n<li>rosa Sola alberich (vocal)<\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<li>pedro Montilla lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Dolores Adarraga Cansino Introduccion el pai-1 es el principal modulador de la fibrinolisis por su acci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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