{"id":12567,"date":"2018-03-09T08:58:28","date_gmt":"2018-03-09T08:58:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-alometrico-del-comportamiento-cinetico-del-tianfenicol-en-diferentes-especies-animales\/"},"modified":"2018-03-09T08:58:28","modified_gmt":"2018-03-09T08:58:28","slug":"estudio-alometrico-del-comportamiento-cinetico-del-tianfenicol-en-diferentes-especies-animales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-alometrico-del-comportamiento-cinetico-del-tianfenicol-en-diferentes-especies-animales\/","title":{"rendered":"Estudio alom\u00e9trico del comportamiento cin\u00e9tico del tianfenicol en diferentes especies animales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gl\u00f3ria Castells Carles <\/strong><\/h2>\n<p>El objetivo principal  de la tesis doctoral fue la b\u00fasqueda de una herramienta que permitiera la predicci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos del tianfenicol tap un antibi\u00f3tico de amplio espectro, en cualquier especie, a partir de las relaciones alom\u00e9tricas establecidas entre siete especies animales, rat\u00f3n, rata, conejo, perro, cerdo, oveja y ternero.  en primer lugar, se estudi\u00f3 el comportamiento cin\u00e9tico del f\u00e1rmaco en cada una de las especies mediante los par\u00e1metros farmacocin\u00e9ticos principales (volumen de distribuci\u00f3n aparente, aclarado plasm\u00e1tico y semivida plasm\u00e1tica), calculados a partir de les curvas tiempo-concentraci\u00f3n plasm\u00e1tica de cada animal.  estas curvas se elaboraron apartir de la administraci\u00f3n de una dosis terap\u00e9utica de tap per v\u00eda iv y la toma de muestras de sangre a diferentes tiempos, muestras que se analizaron mediante una t\u00e9cnica de hplc (high performance liquid chromatography) para cuantificar la presencia de tap en cada una.  el paso siguiente consisti\u00f3 en calcular las ecuaciones alom\u00e9tricas para cada par\u00e1metro farmacocin\u00e9tico, representando en una escala logar\u00edtmica el peso de la especie frente al valor del par\u00e1metro en cada una, y realizando un an\u00e1lisis de regresi\u00f3n lineal  de la recta obtenida. Paralelamente, se estudiaron diferentes unidades de tiempo farmacocin\u00e9tico (unidades de tiempo obtenidas apartir de la transformaci\u00f3n del tiempo cronol\u00f3gico mediante un par\u00e1metro fisiol\u00f3gico del animal, transformaci\u00f3n que ofrece un tiempo invariable entre especies), para encontrar aquella unidad que mejor defin\u00eda la disposici\u00f3n del tap en todas les especies estudiadas.  para acabar, se efectu\u00f3 una predicci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos del tap en cada especie seg\u00fan su peso, apartir de las ecuaciones alom\u00e9tricas y de la undiad de tiempo famacocin\u00e9tico que mejor defin\u00eda el comportamiento del tap en todas les especies (apolysichrons, en este caso). Se calcul\u00f3 la exa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio alom\u00e9trico del comportamiento cin\u00e9tico del tianfenicol en diferentes especies animales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio alom\u00e9trico del comportamiento cin\u00e9tico del tianfenicol en diferentes especies animales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gl\u00f3ria Castells Carles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carles Crist\u00f3fol Adell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Domenech berrozpe <\/li>\n<li> San Andr\u00e9s larrea Manuel (vocal)<\/li>\n<li>josep Torrent farnell (vocal)<\/li>\n<li>Carlos P\u00e9rez villota (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gl\u00f3ria Castells Carles El objetivo principal de la tesis doctoral fue la b\u00fasqueda de una herramienta que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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