{"id":12610,"date":"2001-08-08T00:00:00","date_gmt":"2001-08-08T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/supervivencia-recidiva-y-progresion-del-carcinoma-de-celulas-transicionales-de-vejiga-en-estados-t1-y-t2a-valor-pronostico-de-p53-y-ki67\/"},"modified":"2001-08-08T00:00:00","modified_gmt":"2001-08-08T00:00:00","slug":"supervivencia-recidiva-y-progresion-del-carcinoma-de-celulas-transicionales-de-vejiga-en-estados-t1-y-t2a-valor-pronostico-de-p53-y-ki67","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/supervivencia-recidiva-y-progresion-del-carcinoma-de-celulas-transicionales-de-vejiga-en-estados-t1-y-t2a-valor-pronostico-de-p53-y-ki67\/","title":{"rendered":"Supervivencia, recidiva y progresi\u00f3n del carcinoma de c\u00e9lulas transicionales de vejiga en estados t1 y t2a valor pron\u00f3stico de p53 y ki67."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Rodr\u00edguez Alonso <\/strong><\/h2>\n<p>Los objetivos del estudio fueron, en primer lugar, determinar como la expresi\u00f3n inmunohistoqu\u00edmica de p53 y ki67, cuantificada en las categor\u00edas tis t1 y t2a, en el momento del diagn\u00f3stico del tumor primario, afecta a la supervivencia general y c\u00e1ncer-relacionada, la recidiva y la progresi\u00f3n del c\u00e1ncer de vejiga. En segundo lugar, determinar factores cl\u00ednico-patol\u00f3gicos asociados al pron\u00f3stico de la enfermedad.  se realiz\u00f3 un estudio observacional de cohorte retrospectivo y prospectivo, con una muestra de 219 pacientes con carcinoma primario de vejiga en estadio cl\u00ednico tis (n=9), t1 (n=175) y t2a no mo (n=35. Se estudiaron un total de 177 variables. Los anticuerpos monoclonales utilizados fueron do7 (p53) y mib-1 (ki67).  se estim\u00f3 el pron\u00f3stico mediante la metodolog\u00eda de kaplan-meier. Se realiz\u00f3 asimismo un an\u00e1lisis multivariado de riesgos proporcinales de cox. las variables cuantitativas p53 y ki67 fueron categorizadas en cuartiles,para incrementar el poder estad\u00edstico y para poder discriminar entre los diferentes grupos.  el seguimiento medio de los pacientes fue de 6,7 a\u00f1os. La supervivencia general a los 5 y 10 a\u00f1os fue 68,48% y 46,62%, respectivamente. Las variables independientes de supervivencia c\u00e1ncer-relacionada en la categor\u00eda t1 fueron: edad, tama\u00f1o tumoral &gt;3 cm, morofolog\u00eda microsc\u00f3pica s\u00f3lida del tumor, y expresi\u00f3n de p53. En la categor\u00eda t2a, las variables independietnes fueron: edad y grado histol\u00f3gico 3. La supervivencia libre de recidiva a los 5 y 10 a\u00f1os fue 51,80% y 42,71% respectivamente. Las variables independientes de recidiva en la categor\u00eda t1 fueron: multifocalidad tumoral, tama\u00f1o tumoral &gt; 3cm, presencia de carcinoma in situ en la biopsia randomizada de vejiga, y expresi\u00f3n de ki67. No se observ\u00f3 ninguna variable independiente de recidiva en los tumores de la categor\u00eda t2a. Las variables independientes de progresi\u00f3n en la categor\u00eda t1 fueron: edad, multifocalidad tum<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Supervivencia, recidiva y progresi\u00f3n del carcinoma de c\u00e9lulas transicionales de vejiga en estados t1 y t2a valor pron\u00f3stico de p53 y ki67.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Supervivencia, recidiva y progresi\u00f3n del carcinoma de c\u00e9lulas transicionales de vejiga en estados t1 y t2a valor pron\u00f3stico de p53 y ki67. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Rodr\u00edguez Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/08\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Nogueira March Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Teijeiro vidal <\/li>\n<li>Luis angel Rioja sanz (vocal)<\/li>\n<li>Luis Resel est\u00e9vez (vocal)<\/li>\n<li>federico Rodriguez-rubio vidal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Rodr\u00edguez Alonso Los objetivos del estudio fueron, en primer lugar, determinar como la expresi\u00f3n inmunohistoqu\u00edmica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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