{"id":12649,"date":"2001-07-09T00:00:00","date_gmt":"2001-07-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-y-farmacodinamico-del-rocuronio-en-pacientes-sometidos-a-trasplante-hepaticos\/"},"modified":"2001-07-09T00:00:00","modified_gmt":"2001-07-09T00:00:00","slug":"estudio-farmacocinetico-y-farmacodinamico-del-rocuronio-en-pacientes-sometidos-a-trasplante-hepaticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-y-farmacodinamico-del-rocuronio-en-pacientes-sometidos-a-trasplante-hepaticos\/","title":{"rendered":"Estudio farmacocinetico y farmacodinamico del rocuronio en pacientes sometidos a trasplante hep\u00e1ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Encarnaci\u00f3n Morales Vera <\/strong><\/h2>\n<p>La utilizaci\u00f3n de f\u00e1rmacos bloqueantes neuromusculares (bnm), es pr\u00e1cticamente imprescindible en cirug\u00eda abdominal.La aparici\u00f3n de neuvos bnm, hace necesaria la realizaci\u00f3n de estudios, lo m\u00e1s amplios posibles, con objeto de poder ofrecer a nuestros pacientes la mayor seguridad en cuanto a manejo anest\u00e9sico de los procedimientos quir\u00fargicos, especialmente en pacientes de alto riesgo con fallos multiorg\u00e1nicos (en cirug\u00edas altamente agresivas, tales como la cirug\u00eda del trasplante hep\u00e1tico).  por ello, el objetivo de esta tesis es la evaluaci\u00f3n fc y fd de un bnm, bromuro de rocuronio, en pacientes normales y con insuf. Hep\u00e1tica extrema, sometidos a trasplante hep\u00e1tico, determinando entre otras, las microcosntantes de paso a distintos compartimentos. Comparamos igualmente las modificaciones hemodin\u00e1mica sy cardiovasculares durante todo el proceso quir\u00fargico en ambos grupos de pacientes; siete de ellos sometidos al trasplante hep\u00e1tico, y otros siete como pacientes control, sometidos a cirug\u00eda de larga duraci\u00f3n convencional. En todos ellos la anestesia se indujo con tiopental i.V. la relajaci\u00f3n muscular e intubaci\u00f3n se realizaron con una dosis bolo de rocuronio de 0,6 mg\/kg, el mantenimiento con midazolam y fentanilo a demanda y rocuronio en perfusi\u00f3n continua, de acuerdo a la profundiad del bloqueo neuromuscular, seg\u00fan el registro acelerom\u00e9trico. Se mantuvo aisistida la ventilaci\u00f3n en ambos grupos controlando normocarbia. Se monitoriz\u00f3 ecg continuo, frecuencia card\u00edaca y presiones arteriales no invasivas cada cinco minutos (grupo control) y perfil hemodinamico en cada una de las tres fases del trasplante: con cat\u00e9ter de swan-ganz, cat\u00e9ter de fracci\u00f3n de eyecci\u00f3n del ventr\u00edculo derecho, etc. Las distintas variables farmacodinamicas se obtuvieron en ambos grupos por acelerometr\u00eda, estimulando el nervio cubital a nivel de la mu\u00f1eca con trenes de cuatro est\u00edmulos cada 15 segundos. las determinaciones del f\u00e1rmac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico y farmacodinamico del rocuronio en pacientes sometidos a trasplante hep\u00e1ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico y farmacodinamico del rocuronio en pacientes sometidos a trasplante hep\u00e1ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Encarnaci\u00f3n Morales Vera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Brugger Auban<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: asuncion (secretario) Cremades campos <\/li>\n<li>Francisco Gonz\u00e1lez ru\u00edz (vocal)<\/li>\n<li> Castillo ferrando Juan  ram\u00f3n (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Encarnaci\u00f3n Morales Vera La utilizaci\u00f3n de f\u00e1rmacos bloqueantes neuromusculares (bnm), es pr\u00e1cticamente imprescindible en cirug\u00eda abdominal.La aparici\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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