{"id":12681,"date":"2001-11-09T00:00:00","date_gmt":"2001-11-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-bioqua%c2%admicos-del-remodelado-oseo-aplicacion-en-la-especie-canina-a-partir-de-un-modelo-experimental-de-osteoporosis-y-un-ensayo-terapeutico-en-ratas\/"},"modified":"2001-11-09T00:00:00","modified_gmt":"2001-11-09T00:00:00","slug":"marcadores-bioqua%c2%admicos-del-remodelado-oseo-aplicacion-en-la-especie-canina-a-partir-de-un-modelo-experimental-de-osteoporosis-y-un-ensayo-terapeutico-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/marcadores-bioqua%c2%admicos-del-remodelado-oseo-aplicacion-en-la-especie-canina-a-partir-de-un-modelo-experimental-de-osteoporosis-y-un-ensayo-terapeutico-en-ratas\/","title":{"rendered":"Marcadores bioqu\u00edmicos del remodelado \u00f3seo: aplicaci\u00f3n en la especie canina a partir de un modelo experimental de osteoporosis y un ensayo terap\u00e9utico en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat P\u00e9rez Pi\u00f1ero <\/strong><\/h2>\n<p>Las bases del estudio del recambio esquel\u00e9tico del perro se estudian en ratas ovariectomizadas sprague-dawley por medio de marcadores bioqu\u00edmicos del remodelado \u00f3seo.  en ratas viejas, la ovariectom\u00eda  causa el desequilibrio del remodelado \u00f3seo como ponen de manifiesto algunos marcadores de la resorci\u00f3n \u00f3sea (dpir\/crea) que se modifican significativamente cuando el descenso de estr\u00f3genos es brusco. Otros marcadores lo hacen (%dpir, ca\/crea) en una fase m\u00e1s tard\u00eda (6 meses). De forma paralela, cambian los niveles s\u00e9ricos de algunos marcadores de la formaci\u00f3n (bgp, alp) ante la deficiencia hormonal. El tratamiento con antirresortivos (estr\u00f3genos, pamidronato y calcitonina) permite modificar algunos par\u00e1metros bioqu\u00edmicos de la formaci\u00f3n (alp, bgp) y la resorci\u00f3n (dpir\/crea, p&lt;0,0001) y evaluar la capacidad onteorregeneradora de cada f\u00e1rmaco. Tambi\u00e9n se comprobaron los efectos derivados de la ovariectom\u00eda y el tratamiento antirresortivo sobre el peso corporal en ratas de laboratorio. la densitometr\u00eda \u00f3sea del cuerpo total confirma la reducci\u00f3n de la dmo tras la ovariectom\u00eda y la histolog\u00eda de tibia y v\u00e9rtebra demuestra el emperoamiento de la microarquitectura trabecular al comparar piezas \u00f3seas de ratas enteras y operadas.  en perros sanos, los niveles de marcadores bioqu\u00edmicos del remodelado, musculares y minerales se modifican en funci\u00f3n de las caracter\u00edsticas individuales del perro y de la presencia de lesiones degenerativas en la columna vertebral. los perros j\u00f3venes adultos tienen un remodelado acoplado (equilibrado) y m\u00e1s pronunciado que los de edad avanzada, que tienden al desequilibrio del remodelado (desacoplamiento). Las hembras eliminan mayor tasa de pir\/crea en orina que los machos y la raza pastor alem\u00e1n de dpir. Tambi\u00e9n se modifican en espondilosis y artrosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores bioqu\u00edmicos del remodelado \u00f3seo: aplicaci\u00f3n en la especie canina a partir de un modelo experimental de osteoporosis y un ensayo terap\u00e9utico en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores bioqu\u00edmicos del remodelado \u00f3seo: aplicaci\u00f3n en la especie canina a partir de un modelo experimental de osteoporosis y un ensayo terap\u00e9utico en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat P\u00e9rez Pi\u00f1ero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Verde Arribas M. Teresa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Rodr\u00edguez <\/li>\n<li>Jes\u00fas Mu\u00f1oz Mar\u00eda (vocal)<\/li>\n<li> Marca Andr\u00e9s Mar\u00eda  carmen (vocal)<\/li>\n<li>lLuis Lujan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat P\u00e9rez Pi\u00f1ero Las bases del estudio del recambio esquel\u00e9tico del perro se estudian en ratas ovariectomizadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,35,515,5562,541,13610,226],"tags":[41398,41400,41397,41399,41396,29021],"class_list":["post-12681","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-de-la-vida","category-ciencias-veterinarias","category-medicina-interna-veterinaria","category-patologia-animal","category-zaragoza","category-zoologia","tag-jesus-munoz-maria","tag-lluis-lujan","tag-manuel-rodriguez","tag-marca-andres-maria-carmen","tag-montserrat-perez-pinero","tag-verde-arribas-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12681","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12681"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12681\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12681"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12681"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12681"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}