{"id":12698,"date":"2018-03-09T08:58:40","date_gmt":"2018-03-09T08:58:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celulas-dendra%c2%adticas-en-la-dermatomiositis-estudio-en-piel-musculo-y-lesiones-cutaneas-fotoinducidas\/"},"modified":"2018-03-09T08:58:40","modified_gmt":"2018-03-09T08:58:40","slug":"celulas-dendra%c2%adticas-en-la-dermatomiositis-estudio-en-piel-musculo-y-lesiones-cutaneas-fotoinducidas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/celulas-dendra%c2%adticas-en-la-dermatomiositis-estudio-en-piel-musculo-y-lesiones-cutaneas-fotoinducidas\/","title":{"rendered":"C\u00e9lulas dendr\u00edticas en la dermatomiositis. estudio en piel, m\u00fasculo y lesiones cut\u00e1neas fotoinducidas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Schepers Gassner M. Christina <\/strong><\/h2>\n<p>La dm es una enfermedad sist\u00e9mica de probable origen autoinmune que afecta principalmente a piel y a m\u00fasculo. Se postula que en la dm ocurre una reacci\u00f3n inmune aberrante desencadenada por unos factores externos en un individuo gen\u00e9ticamente predispuesto.  los objetivo de esta tesis fueron caracterizar las c\u00e9lulas de morfolog\u00eda dendr\u00edtica (en especial las c\u00e9lulas dendr\u00edticas factor xiiia las cd34 positivas), su relaci\u00f3n con los infiltrados inflamatorios, mol\u00e9culas de adhesi\u00f3n y el complejo de ataque de membrana (mac), tanto en piel como en m\u00fasculo. por otro lado, se ha establecido el grado de fotosensibilidad y se han estudiado las c\u00e9lulas dendr\u00edticas y el mac en lesiones fotoinducidas.  el n\u00famero de c\u00e9lulas dendr\u00edticas factor xiiia + est\u00e1 muy disminu\u00eddo en las lesiones cut\u00e1neas de dm respecto a piel sana y no forman parte significativa de los infiltrados inflamatorios de la dm. No existen c\u00e9lulas factor xiiia + (al igual que tampoco existen c\u00e9lulas de langerhans) en m\u00fasculo. El n\u00famero de c\u00e9lulas dendr\u00edticas cd34 + est\u00e1 aumentado en el intersticio de la dermis de las lesiones cut\u00e1neas de dm, aunqeu se observa una disminuci\u00f3n de las mismas en la zona perivascular. Las c\u00e9lulas cd34 + est\u00e1n aumentadas en el tejido septal e invaden el m\u00fasculo afectado de dm. El heca-452 (marcador del ant\u00edgeno asociado al linfocito cut\u00e1neo (cla)) se expresa en las c\u00e9lulas de los infiltrados inflamatorios cut\u00e1neos pero no en m\u00fasculo. Demostramos que el cla participa en el reclutamiento espec\u00edfico de las c\u00e9lulas inflamatorias hacia la piel afectada de dm. El estudio de los dep\u00f3sitos de mac en las lesiones cut\u00e1neas fotoinducidas muestra ya su presencia en las muestras obtenidas por biopsia a las 6 horas despu\u00e9s de la exposici\u00f3n lum\u00ednica. esta observaci\u00f3n apoya la teor\u00eda que supone la participaci\u00f3n precoz del mac en el desarrollo de las lesiones inflamatorias de piel y m\u00fasculo en la dm.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>C\u00e9lulas dendr\u00edticas en la dermatomiositis. estudio en piel, m\u00fasculo y lesiones cut\u00e1neas fotoinducidas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 C\u00e9lulas dendr\u00edticas en la dermatomiositis. estudio en piel, m\u00fasculo y lesiones cut\u00e1neas fotoinducidas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Schepers Gassner M. Christina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Herrero Mateu<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Mar\u00eda Grau junyent <\/li>\n<li>mario Lecha carralero (vocal)<\/li>\n<li>jaume Ordi (vocal)<\/li>\n<li>isabel Bielsa marsol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Schepers Gassner M. Christina La dm es una enfermedad sist\u00e9mica de probable origen autoinmune que afecta principalmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,155,9,97],"tags":[13914,41459,41458,29494,20039,41457],"class_list":["post-12698","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-clinicas","category-ciencias-medicas","category-dermatologia","tag-carmen-herrero-mateu","tag-isabel-bielsa-marsol","tag-jaume-ordi","tag-josep-maria-grau-junyent","tag-mario-lecha-carralero","tag-schepers-gassner-m-christina"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12698"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12698\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}