{"id":12724,"date":"2018-03-09T08:58:42","date_gmt":"2018-03-09T08:58:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-d-ela-iontoforesis-transdermica-para-la-administracion-sistemica-del-antiparkinsoniano-monoclorhidrato-de-ropinirol-estudios-in-vitro-e-in-vivo\/"},"modified":"2018-03-09T08:58:42","modified_gmt":"2018-03-09T08:58:42","slug":"aplicacion-d-ela-iontoforesis-transdermica-para-la-administracion-sistemica-del-antiparkinsoniano-monoclorhidrato-de-ropinirol-estudios-in-vitro-e-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-d-ela-iontoforesis-transdermica-para-la-administracion-sistemica-del-antiparkinsoniano-monoclorhidrato-de-ropinirol-estudios-in-vitro-e-in-vivo\/","title":{"rendered":"Aplicaci\u00f3n d ela iontoforesis transd\u00e9rmica para la administraci\u00f3n sist\u00e9mica del antiparkinsoniano monoclorhidrato de ropinirol. estudios in vitro e in vivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Asteria M. Luzardo Alvarez <\/strong><\/h2>\n<p>En la presente memoria experimental se aborda el estudio de la viabilidad de la t\u00e9cncia de iontoforesis comot\u00e9cnica de administraci\u00f3n de una gonista de la dopamina, monoclorhidrato de ropinirol, para el tratamiento de la enfermedad de parkinson.  se conoce como iontoforesis a la t\u00e9cnica que mediante peque\u00f1as intensidades de corriente el\u00e9ctrica provoca el movimiento de iones a trav\u00e9s de una membrana (la piel) por acci\u00f3n del campo el\u00e9ctrico creado. Los mecanismso que intervienen durante la iontoforesis de un f\u00e1rmaco son la electro-repulsi\u00f3n y la electro\u00f3smosis. en primer lugar se procedi\u00f3 al estudio de las propiedades de permeabilidad selectiva de la piel de cerdo neonato. Se trataba de una caracterizaci\u00f3n necesaria del modeloanimal disponible para la realizaci\u00f3n de estos estudios y para evaluar la contribuci\u00f3n de la electro-repulsi\u00f3n y la electro\u00f3smosis al transporte iontofor\u00e9tico total. En esos estudios se determin\u00f3 el n\u00famero de transporte del i\u00f3n sodio, el punto isoel\u00e9ctrico de la piel de cerdo neonato y se evalu\u00f3 su idoneidad como alternativa adecuada en la evaluaci\u00f3n de la contribuci\u00f3n electroosm\u00f3tica al flujo iontofor\u00e9tico.  en segundo ludar, se determinaron los factores clave que controlan el electrotrasnporte del f\u00e1rmaco seleccionado in vitro y el efecto de \u00e9stos sobre el electrotranaporte del ropinirol. Se caracteriz\u00f3 su electrotransporte en presencia y ausencia de ionescompetidores, el efecto de la concentraciones de cloruro s\u00f3dico, el efecto de la concentraci\u00f3n de principio activo y la de la intensidad de corriente sobre el flujo iontofor\u00e9tico de ropinirol. en estos estudios se utilizaron c\u00e9lulas lado a lado y piel de cerdo neonato. para la determinaci\u00f3n anal\u00edtica del principio activo en las muestras se ha utilizado un m\u00e9todo de cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n. Se pudo comprobar como el flujo por iontoforesis del ropinirol en presencia de otros iones no depende de la fracci\u00f3n mol<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n d ela iontoforesis transd\u00e9rmica para la administraci\u00f3n sist\u00e9mica del antiparkinsoniano monoclorhidrato de ropinirol. estudios in vitro e in vivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n d ela iontoforesis transd\u00e9rmica para la administraci\u00f3n sist\u00e9mica del antiparkinsoniano monoclorhidrato de ropinirol. estudios in vitro e in vivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Asteria M. Luzardo Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Blanco M\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Mart\u00ednez pacheco <\/li>\n<li>patrizia Santi (vocal)<\/li>\n<li>h. Guy richard (vocal)<\/li>\n<li>virginia Merino saju\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Asteria M. Luzardo Alvarez En la presente memoria experimental se aborda el estudio de la viabilidad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,17648,977],"tags":[41536,26101,21090,41537,3307,41538],"class_list":["post-12724","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-procesos-metabolicos-de-los-farmacos","category-santiago-de-compostela","tag-asteria-m-luzardo-alvarez","tag-h-guy-richard","tag-jose-blanco-mendez","tag-patrizia-santi","tag-ramon-Martinez-pacheco","tag-virginia-merino-sajuan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12724"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12724\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}