{"id":12821,"date":"2018-03-09T08:58:50","date_gmt":"2018-03-09T08:58:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-sobre-la-profilaxi-de-la-fibrinolisi-en-el-trasplantament-hepatic-ortotopic-amb-analegs-de-la-lisina\/"},"modified":"2018-03-09T08:58:50","modified_gmt":"2018-03-09T08:58:50","slug":"estudi-sobre-la-profilaxi-de-la-fibrinolisi-en-el-trasplantament-hepatic-ortotopic-amb-analegs-de-la-lisina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudi-sobre-la-profilaxi-de-la-fibrinolisi-en-el-trasplantament-hepatic-ortotopic-amb-analegs-de-la-lisina\/","title":{"rendered":"Estudi sobre la profilaxi de la fibrinolisi en el trasplantament hepatic ortotopic amb analegs de la lisina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonia Dalmau Llitj\u00f3s <\/strong><\/h2>\n<p>Hemos evaluado la eficacia de la administraci\u00f3n profil\u00e1ctica de los an\u00e1logos de la lisina en la reducci\u00f3n de los requerimientos de hemoderivados durante el trasplante hep\u00e1tico (th) y hemos analizado el riesgo de trombosis atribuible a la administraci\u00f3n profil\u00e1ctica de estos f\u00e1rmacos.  se estudiaron en dos centros de forma randomizada y a doble ciego 153 th consecutivos. Los pacientes fueron distribuidos en tres grupos y se les administr\u00f3 profil\u00e1cticamente \u00e1cido tenex\u00e1mico (at) a 10 mg\/kg\/h, o \u00e1cido \u00e9psil\u00f3n-aminocaproico (eaca) a 16 mg\/kg\/h o placebo (p, suero fisiol\u00f3gico). el manejo intraoperatorio fue estandarizado. Se controlaron las pruebas de coagulaci\u00f3n, troboelastograma y los requerimientos de hemoderivados durante el th y en las primeras 24 horas postrasplante. La administraci\u00f3n de concentrados de hematies (ch) fue significativamente m\u00e1s baja (p=0,023) en el grupo de at (4,4+-5,2 vs 6+-5,6 en el grupo de eaca y 6,9+-5,2 en el grupo p). No hubo diferencias en las complicaciones tromb\u00f3ticas, reintervenciones ni mortalidad en los tres grupos estudiados.  para establecer la influencia de la profilaxis de la fibrinolisis con at en las complicaciones tromb\u00f3ticas realizamos un segundo estudio prospectivo y a doble ciego en 133 th consecutivos en un \u00fanico centro. Se les administr\u00f3 at de forma profil\u00e1ctica y a la misma dosis que en el primer estudio. Se realiz\u00f3 eco-doppler sistem\u00e1tico para controlar la permeabilidad de las anast\u00f3mosis vasculares a todos los pacientes y en el caso de dudas se realiz\u00f3 arteriografia selectiva del tronco cel\u00edaco. Los resultados confirmaron la reducci\u00f3n de la transfusi\u00f3n de ch (2,93+-2,98) y el porcentaje de trombosis arterial precoz (tap 4,9%) y retrasplante por tap (2,5%) fueron comparables al estudio previo y a los descritos por la literatura. No se observaron otras complicaciones tromb\u00f3ticas.  concluimos que la administraci\u00f3n profil\u00e1ctica de \u00e1cido tranex\u00e1mico reduce de f<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi sobre la profilaxi de la fibrinolisi en el trasplantament hepatic ortotopic amb analegs de la lisina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi sobre la profilaxi de la fibrinolisi en el trasplantament hepatic ortotopic amb analegs de la lisina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonia Dalmau Llitj\u00f3s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antoni Sabate Pes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio (secretario) Ramos rubio <\/li>\n<li> Octavio de toledo malo m. carmen (vocal)<\/li>\n<li>Francisco Acosta villegas (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonia Dalmau Llitj\u00f3s Hemos evaluado la eficacia de la administraci\u00f3n profil\u00e1ctica de los an\u00e1logos de la lisina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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