{"id":128586,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-electrofisiologicos-de-la-zatebradina-en-preparaciones-cardiacas-aisladas\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"efectos-electrofisiologicos-de-la-zatebradina-en-preparaciones-cardiacas-aisladas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-electrofisiologicos-de-la-zatebradina-en-preparaciones-cardiacas-aisladas\/","title":{"rendered":"Efectos electrofisiologicos de la zatebradina en preparaciones cardiacas aisladas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gay Puente M. Pilar <\/strong><\/h2>\n<p>En esta tesis doctoral hemos estudiado los efectos electrofisiologicos de la zatebradina (zat), un nuevo bradicardizante selectivo. En musculos papilares de cobayo, la zat ( 5 m) inhibe la velocidad maxima de despolarizacion (vmax) del potencial de accion cardiaco y ejerce un efecto bifasico sobre su duracion, prolongandola a aconcentraciones  5 m, mientras que la acorta a concentraciones 10  m. La zat produce un bloqueo tonico (8.2 +- 1.0%) y un bloqueo frecuencia-dependiente (bfd) de la vmax (0,5-3hz: 17.2+-1.5-49.3+-2.1%). A 2 hz, la cinetica de aparicion del bfd era de 0.32+- 0.02 ap-1 y la constante de tiempo de recuperacion ( re) de 2.9+-0.1s. La zat desplaza la capacidad de respuesta de la membrana en direccion hiperbolarizante, lo que sugiere quese une al estado inactivo del canal de na+. Es decir, que la zat presenta propiedades antiarritmicas de los grupos ia y iii. Para explicar este ultimo efecto, estudiamos las acciones de la zat sobre un canal cardiaco de k+ clonado de ventriculo humano (hkv1.5) expresado en fibroblastos de raton (ltk) utilizando la tecnica de parche de membrana. La zat (0.1-100  m) inhibe la corriente hkv1.5 (kd = 1.8+-0.14  m) en el rango de activacion del canal, lo que indica que se une al estado abierto del mismo. La forma cationica de la zat actua desde el interior de la celula atravesado un 18% del campo electrico de membrana para alcanzar su sitio receptor (  =0.177 +-0.002). La zat tambien aumenta la constante de tiempo de reactivacion y prolonga la  re(0.8+-0.2s vs 1.6+-0.2s) por lo que induce un bfd de la corriente hkv1.5. Por tanto, la zat bloquea el estado abierto del canal hkv1.5 de forma concentracion-,voltaje-, tiempo- y frecuencia-dependiente. Este efecto explica porque la zat presenta propiedades antiarritmicas del grupo iii.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos electrofisiologicos de la zatebradina en preparaciones cardiacas aisladas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos electrofisiologicos de la zatebradina en preparaciones cardiacas aisladas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gay Puente M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Tamargo Men\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar Del Fresno <\/li>\n<li>Mercedes Salaices S\u00e1nchez (vocal)<\/li>\n<li>Francisco Zaragoza Garcia (vocal)<\/li>\n<li>Alfonso Moreno Sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gay Puente M. Pilar En esta tesis doctoral hemos estudiado los efectos electrofisiologicos de la zatebradina (zat), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,986,957],"tags":[241855,4663,4080,241854,4665,5260],"class_list":["post-128586","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-complutense-de-madrid","category-farmacologia","tag-alfonso-moreno-sanchez","tag-angel-villar-del-fresno","tag-francisco-zaragoza-garcia","tag-gay-puente-m-pilar","tag-juan-luis-tamargo-menendez","tag-mercedes-salaices-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=128586"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128586\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=128586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=128586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=128586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}