{"id":128592,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/virus-herpes-simplex-resistentes-a-drogas-antivirales-incidencia-y-significacion-clinica-en-pacientes-inmunocomprometidos\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"virus-herpes-simplex-resistentes-a-drogas-antivirales-incidencia-y-significacion-clinica-en-pacientes-inmunocomprometidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/virus-herpes-simplex-resistentes-a-drogas-antivirales-incidencia-y-significacion-clinica-en-pacientes-inmunocomprometidos\/","title":{"rendered":"Virus herpes simplex resistentes a drogas antivirales: incidencia y significacion clinica en pacientes inmunocomprometidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Gimeno Fernandez <\/strong><\/h2>\n<p>El virus herpes simplex es una de las principales causas de infeccion viral en pacientes inmunodeprimidos, en los que son frecuentes los cuadros atipicos, graves y cronicos. El aciclovir (acv) es el tratamiento de eleccion ya que inhibe selectiva y especificamente la replicacion viral. Sin embargo ya se han descrito infecciones por cepas mutantes resistentes. Los objetivos de este estudio son: 1) determinar la preValencia de infeccion herpetica resistente a acv en pacientes inmunodeprimidos y los factores de riesgo asociados a ella. 2) analizar la relacion entre la sensibilidad \u00abin vitro\u00bb y la respuesta clinica a la terapia antiviral comuunmente recomendada. 3) comparar tres metodos de estudio de sensibilidad y analizar su posible aplicacion a la rutina de un laboratorio. Para ello, se estudio la sensibilidad de 303 cepas procedentes de 198 pacientes (99 trasplantados de organo solido, 46 enfermos hematologicos y 53 pacientes infectados por vih), entre junio de 1992 y febrero de 1994. Como metodo de \u00abscreening\u00bb de sensibilidad a acv se utilizo el de hibridacion con dos concentraciones de droga antiviral.  en todas las cepas resistentes se determino la ic-50 para foscarnet. Ademas en 74 de esta cepas se determino la ic-50 para acv mediante el metodo de hibridacion, el colorimetrico y el de reduccion del efecto citopatico (ecp). La preValencia de resistencia acv fue del 9,1%, aunque variable segun el grupo considerado (del 15,1% en infectados por vih, del 8,7% en los enfermos hematologicos y del 6% en recptores de organo solido). El tratamiento previo con antivirales analogos de los nucleosidos y el aislamiento del serotipo viral 2 influyeron en una mayor tasa de resistencia. En los receptores de organo solido tambien influyeron el antecedente de rechazo agudo y el tratamiento con anticuerpos anti-okt3 en el mes previo. La frecuencia de infeccion sintomatica fue similar entre los pacientes con aislamientos sensibles (71,7%) y los p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Virus herpes simplex resistentes a drogas antivirales: incidencia y significacion clinica en pacientes inmunocomprometidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Virus herpes simplex resistentes a drogas antivirales: incidencia y significacion clinica en pacientes inmunocomprometidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Gimeno Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Joaquin Rodr\u00edguez Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Beltr\u00e1n Dub\u00f3n <\/li>\n<li>Antonio Guerrero Espejo (vocal)<\/li>\n<li>Luis Iglesias Diez (vocal)<\/li>\n<li>Eva Palenque Mataix (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Gimeno Fernandez El virus herpes simplex es una de las principales causas de infeccion viral en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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