{"id":128612,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-cuantificacion-de-la-oncoproteina-p53-en-el-carcinoma-broncogenico-no-microcitico-valor-pronostico\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-la-cuantificacion-de-la-oncoproteina-p53-en-el-carcinoma-broncogenico-no-microcitico-valor-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-cuantificacion-de-la-oncoproteina-p53-en-el-carcinoma-broncogenico-no-microcitico-valor-pronostico\/","title":{"rendered":"Estudio de la cuantificacion de la oncoproteina p53 en el carcinoma broncogenico no microcitico: valor pronostico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Gonzalez Lopez <\/strong><\/h2>\n<p>Introduccion: el cancer de pulmon constituye un problema sanitario de primer orden. En el momento de diagnostico solo el 30% de los pacientes se encuentra en estadio precoz (i,iiia). La supervivencia a los cinco a\u00f1os no supera el 15%. Por ello, se intenta encontrar nuevos parametros biologicos que sirvan para conocer el pronostico de los pacientes afectos por cancer broncogenico, para poder utilizar tratamientos mas individualizados que mejoren la supervivencia.  objetivos: determinar la oncoproteina p53 y conocer que influencia podia ejercer en el pronostico de los pacientes con cancer de pulmon.  pacientes y metodo: se han incluido 97 pacientes, intervenidos en nuestro hospital entre febrero de 1984 y mayo de 1994. El grupo estaba formado por 77 pacientes intervenidos por cancer de pulmon y 20 (grupo control) intervenidos por neumotorax. La distribucion de los pacientes del grupo cancer fue: 74 varones y 3 mujeres.  edad media de 63,8 a\u00f1os (r: 31-79). La clasificacion por estadios resulto: i,40 pacientes (51,9%), ii, 3 pacientes (3,9%), iiia, 22 (28,6%), iiib, 6 pacientes (7,8%) y iv, 6 pacientes (7,8%). Al tipo histologico epidermoide pertenecian 45 enfermos (58,4%), al adenocarcinoma, 20 enfermos (26%), al indiferenciado de celulas grandes, 9 enfermos y al tipo adenoescamoso 3 enfermos (3,9%). Se determino la oncoproteina p53 en el citosol de las muestras obtenidas del tumor, de tejido no tumoral de los enfermos del grupo cancer y del tejido pulmonar de los enfermos intervenidos por neumotorax. El metodo utilizado para la cuantificacion fue un lia (inmunoluminisceccia) con dos anticuerpos monoclonales (do1 y pab 1801). El seguimiento medio fue de 20 meses +\/-13 (r: 1-67 meses).  el analisis estadistico se realizo mediante el metodo de kaplan y meier comparando supervivencia mediante el test de breslow. Se aplico la regresion de modelos de cox para el analisis multivariante. Resultados: se detecto p53 en 50 (64,9%) de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la cuantificacion de la oncoproteina p53 en el carcinoma broncogenico no microcitico: valor pronostico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la cuantificacion de la oncoproteina p53 en el carcinoma broncogenico no microcitico: valor pronostico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Gonzalez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias Perez <\/li>\n<li>Alonso Rubial Morell (vocal)<\/li>\n<li>Guillermo Ramos (vocal)<\/li>\n<li> Maestro Castro Mar\u00eda  Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Gonzalez Lopez Introduccion: el cancer de pulmon constituye un problema sanitario de primer orden. En el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,986,347],"tags":[241890,241891,22643,4963,241892,54488],"class_list":["post-128612","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-complutense-de-madrid","category-oncologia-clinica","tag-alonso-rubial-morell","tag-guillermo-ramos","tag-jaime-arias-perez","tag-jose-luis-balibrea-cantero","tag-maestro-castro-maria-luisa","tag-oscar-gonzalez-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=128612"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128612\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=128612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=128612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=128612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}