{"id":128624,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":""},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"sintesis-y-resolucion-enantioselectiva-de-acidos-rs-2-aril-propionicos-empleando-lipasa-de-c-rugosa-y-c-antartica-estudio-de-factores-estructurales-que-condicionan-la-enantioselectividad-del-pro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-resolucion-enantioselectiva-de-acidos-rs-2-aril-propionicos-empleando-lipasa-de-c-rugosa-y-c-antartica-estudio-de-factores-estructurales-que-condicionan-la-enantioselectividad-del-pro\/","title":{"rendered":"Sintesis y resolucion enantioselectiva de acidos (r,s) 2-aril propionicos empleando lipasa de c. rugosa y c. antartica. estudio de factores estructurales que condicionan la enantioselectividad del proceso."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Gradillas Nicolas <\/strong><\/h2>\n<p>La presente tesis doctoral debe enmarcarse dentro de un proyecto de investigacion mas amplio cuyo objetivo final es el desarrollo de una metodolog\u00eda biotecnologica para la obtencion de s(+) acidos 2-aril propionicos con viabilidad industrial, estudiando ademas la influencia de variables estructurales que influyen en el proceso. El trabajo se centra en la sintesis quimica de acidos (r,s) 2-aril propionicos y el desarrollo de un metodo de resolucion enantioselectiva de dichos acidos racemicos.  por esta razon hemos acudido a la resolucion de la mezcla racemica utilizando para ello la hidrolisis enzimatica de los esteres etilicos empleando como catalizador la pipasa de c. Rugosa. Tambien se ha procedido a la resolucion de la mezcla racemica de acidos utilizando la esterificacion enzimatica con la lipasa de c. Antartica. Con objeto de mejorar las enantioselectividades obtenidas se han utilizado meso-tetraaril porfirinas como plataformas de reconocimiento molecular. Se ha descrito ademas el empleo de metales de transicion para la obtencion de mesotetraaril porfirinas por primera vez. Por ultimo se ha llevado a cabo un estudio del centro activo de las dos lipasas empleadas en las resoluciones enzimaticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y resolucion enantioselectiva de acidos (r,s) 2-aril propionicos empleando lipasa de c. rugosa y c. antartica. estudio de factores estructurales que condicionan la enantioselectividad del proceso.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y resolucion enantioselectiva de acidos (r,s) 2-aril propionicos empleando lipasa de c. rugosa y c. antartica. estudio de factores estructurales que condicionan la enantioselectividad del proceso. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Gradillas Nicolas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Llama Hurtado Emilio Fidel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Perez Alvarez-ossorio <\/li>\n<li>Santiago Conde Ruzafa (vocal)<\/li>\n<li>Jos\u00e9 Vicente Sinisterra Gago (vocal)<\/li>\n<li>Pelayo Camps Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Gradillas Nicolas La presente tesis doctoral debe enmarcarse dentro de un proyecto de investigacion mas amplio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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