{"id":128635,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/participacion-del-factor-activador-de-las-plaquetas-paf-y-la-endotelina-1-et-1-en-la-patogenia-del-dano-articular\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"participacion-del-factor-activador-de-las-plaquetas-paf-y-la-endotelina-1-et-1-en-la-patogenia-del-dano-articular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/participacion-del-factor-activador-de-las-plaquetas-paf-y-la-endotelina-1-et-1-en-la-patogenia-del-dano-articular\/","title":{"rendered":"Participacion del factor activador de las plaquetas (paf) y la endotelina-1 (et-1) en la patogenia del da\u00f1o articular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sylvia Gutierrez Erlandsson <\/strong><\/h2>\n<p>Las modificaciones funcionales y estructurales de la membrana sinovial constituyen una de las principales caracteristicas fisiopatologicas de la artritis reumatoide. En este estudio se ha considerado el analisis de las caracteristicas generales de produccion, union y efectos del paf y la et-1 en celulas sinoviales de conejo en cultivo. Los resultados obtenidos indican que los sinoviocitos son capaces de producir paf bioactivo, expresar el precursor prepro-et-1 y unir ambos agentes a traves de un unico tipo de receptores especificos.  ademas, tanto el paf como la et-1 estimulan la transcripcion del protooncogen c-fos e inducen variaciones en cuanto a la produccion de proteoglicanos y fibronectina por los sinoviocitos, efectos que se bloquean mediante el tratamiento de las celulas con antagonistas especificos de sus respectivos receptores.  por otra parte, las actividades pkc y proteina tirosina-quinasa, los metabolitos derivados de la actividad ciclooxigenasa y el tgf- participarian como mecanismos de transduccion de la se\u00f1al inducida por el paf y la et-1 en los sinoviocitos. En conjunto, los resultados obtenidos indican que el paf y la et-1 pueden ser considerados como mediadores que participan en el desarrollo del proceso inflamatorio articular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participacion del factor activador de las plaquetas (paf) y la endotelina-1 (et-1) en la patogenia del da\u00f1o articular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participacion del factor activador de las plaquetas (paf) y la endotelina-1 (et-1) en la patogenia del da\u00f1o articular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sylvia Gutierrez Erlandsson <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Herrero Beaumont Cuenca Gabriel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Emilio Martin Mola (vocal)<\/li>\n<li>Mar\u00eda  Antonia Lizarbe  Iracheta (vocal)<\/li>\n<li>Pedro Sabando Suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sylvia Gutierrez Erlandsson Las modificaciones funcionales y estructurales de la membrana sinovial constituyen una de las principales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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