{"id":128654,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-de-transformacion-oncogenica-del-virus-de-epstein-barr\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-los-mecanismos-de-transformacion-oncogenica-del-virus-de-epstein-barr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-mecanismos-de-transformacion-oncogenica-del-virus-de-epstein-barr\/","title":{"rendered":"Estudio de los mecanismos de transformacion oncogenica del virus de epstein-barr."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Herrero Martinez <\/strong><\/h2>\n<p>El virus de epstein-barr es causante del sindrome de mononucleosis infecciosa, y se ha relacionado con la aparicion de diversos tumores, entre los cuales destacan el carcinoma nasofaringeo, el linfoma de burkitt y las enfermedades linfoproliferativas postrasplante.El virus de epstein-barr es capaz de establecer infecciones latentes en linfocitos b y celulas basales del epitelio nasofaringeo. Durante dichas infecciones latentes, induce la expresion de diversas proteinas, entre las cuales destaca lmp-1 (proteina de latencia de membrana) por sus propiedades oncogenicas. La forma en que esta proteina anclada en la membrana celular induce los cambios en la maquinaria celular necesarios para la transformacion oncogenica son desconocidos, pero probablemente esten implicados algunos factores de transcripcion celular.  en este estudio hemod elegido uno de ellos, el factor nuclear kappa b por su importancia en la regulacion de las funciones activadora y proliferativa en celulas linfoides. Demostramos que lmp-1 es capaz de activar dicho factor de transcripcion de una forma selectiva a traves de la destruccion de unos de sus inhibidores (ikb alfa). Finalmente demostramos que esta activacion del factor nuclear kappa b resulta en una inhibicion del proceso normal de muerte celular programada en estas celulas. Este podria ser el mecanismo final de transformacion oncogenica en las celulas infectadas por el virus de epstein-barr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos de transformacion oncogenica del virus de epstein-barr.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos de transformacion oncogenica del virus de epstein-barr. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Herrero Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>noriega Belaustegui Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Domingo Espinos Perez <\/li>\n<li>Luis Fernandez Guerrero (vocal)<\/li>\n<li>Antonio Pozuelo Gonzalez (vocal)<\/li>\n<li>Jos\u00e9 Alcami Pertejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Herrero Martinez El virus de epstein-barr es causante del sindrome de mononucleosis infecciosa, y se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,986,1085,139,280],"tags":[23313,897,22623,225573,241938,17547],"class_list":["post-128654","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-complutense-de-madrid","category-enfermedades-infecciosas","category-medicina-interna","category-virologia","tag-antonio-pozuelo-gonzalez","tag-domingo-espinos-perez","tag-jose-alcami-pertejo","tag-jose-antonio-herrero-Martinez","tag-luis-fernandez-guerrero","tag-noriega-belaustegui-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=128654"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128654\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=128654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=128654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=128654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}