{"id":128665,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportaciones-al-estudio-de-las-bases-moleculares-de-la-enfermedad-de-alzheimer\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"aportaciones-al-estudio-de-las-bases-moleculares-de-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aportaciones-al-estudio-de-las-bases-moleculares-de-la-enfermedad-de-alzheimer\/","title":{"rendered":"Aportaciones al estudio de las bases moleculares de la enfermedad de alzheimer."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dolores Ibarreta Ruiz <\/strong><\/h2>\n<p>El objetivo general de esta tesis es la deteccion y caracterizacion a nivel celular y molecular de las posibles alteracions estructurales de los genes implicados en la etiopatogenia de la enfermedad de alzheimer.La enfermedad de alzheimer (ea) es la causa mas comun de demencia en los individuos de mediana y avanzada edad. Un estudio europeo a gran escala encontro que 0,4% de las mujeres y 0,3% de los hombres entre los 60 y 69 a\u00f1os, y que 11,2% de mujeres y 10% de los hombre entre los 80 y 89 de la poblacion padecen ea (rocca y col, 1991). Teniendo en cuenta la tendencia de la expectativa de vida media a alargarse, se entiende que la ea se esta convirtiendo en un grave problem para la salud publica.  hemos establecido un banco de lineas celulares inmortales de enfermos de alhzeimer mediante transformacion de linfocitos b con virus de epstein barr. Este modelo experimental, ademas de obviar las dificultades de obtencion de material, ha permitido el estudio de perturbaciones funcionales de indole variada.  el analisis estructural de regiones relavantes del gen que codifica la proteina precursora del peptido b-amiloide en mas de 100 casos de enfermos de alzheimer no ha desvelado la existencia de anomalias.  se ha observado un aumento considerable en la frecuencia del alelo    de la apolipoproteina  e en casos familiares de la enfermedad de alzheimer de aparicion tardia en el area de Madrid.  hemos puesto de manifiesto que en la demencia de alzheimer existen cambios significativos en la homeostasis de             que podrian estar implicados en la etiopatogenia de este proceso. Cambios de esta naturaleza en el medio intracelular pueden ser la causa de alteraciones en la expresion, procesamiento, solubilidad, y\/o funcion de multiples proteinas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaciones al estudio de las bases moleculares de la enfermedad de alzheimer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaciones al estudio de las bases moleculares de la enfermedad de alzheimer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dolores Ibarreta Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matilde S\u00e1nchez Ayuso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alberto Portera Sanchez <\/li>\n<li> Abrisqueta Zarrabe Jos\u00e9 Antonio (vocal)<\/li>\n<li> Martin Rqquero M. Angeles (vocal)<\/li>\n<li> Vazque Lopez-lomo Ana M. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dolores Ibarreta Ruiz El objetivo general de esta tesis es la deteccion y caracterizacion a nivel celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,160,35,986,940,2820,17],"tags":[24538,30022,241950,241951,94555,241952],"class_list":["post-128665","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-bioquimica","category-ciencias-de-la-vida","category-complutense-de-madrid","category-genetica-bioquimica","category-genetica-humana","category-quimica","tag-abrisqueta-zarrabe-jose-antonio","tag-alberto-portera-sanchez","tag-dolores-ibarreta-ruiz","tag-martin-rqquero-m-angeles","tag-matilde-sanchez-ayuso","tag-vazque-lopez-lomo-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=128665"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128665\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=128665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=128665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=128665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}