{"id":12869,"date":"2018-03-09T08:58:55","date_gmt":"2018-03-09T08:58:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cronificacion-de-la-disfuncion-segmentaria-mediante-repeticion-de-procesos-breves-de-isquemia-reperfusion\/"},"modified":"2018-03-09T08:58:55","modified_gmt":"2018-03-09T08:58:55","slug":"cronificacion-de-la-disfuncion-segmentaria-mediante-repeticion-de-procesos-breves-de-isquemia-reperfusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cronificacion-de-la-disfuncion-segmentaria-mediante-repeticion-de-procesos-breves-de-isquemia-reperfusion\/","title":{"rendered":"Cronificaci\u00f3n de la disfunci\u00f3n segmentaria mediante repetici\u00f3n de procesos breves de isquemia\/reperfusi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Andr\u00e9s La Laguna Luis M. <\/strong><\/h2>\n<p>Nuestra hip\u00f3tesis consiste en que la miocardiopat\u00eda de origen isqu\u00e9mico, un mecanismo etiol\u00f3gico importante puede ser la repetici\u00f3n de isquemias transitorias, que podr\u00edan cronificar las alteraciones en la funci\u00f3n segmentaria sin necesidad de necrosis mioc\u00e1rdica previa. Nos planteamos producir sobre una regi\u00f3n mioc\u00e1rdica, etarudida por la aplicaci\u00f3n de un protocolo isqu\u00e9mico (pi) de isquemia breves y repetidas, un 2\u00c2\u00ba pi similar al primero y observar si la recuperaci\u00f3n funcional y estructural es diferente y se estas diferencias van en el sentido de la cronificaci\u00f3n. Nuestros objetivos son el estudiar si las alteraciones que se producen tanto en la funci\u00f3n regional fr, como a nivel del aparato mitocondrial sometido a un 2\u00c2\u00ba pi llegan a recuperarse, medir el tiempo de recuperaci\u00f3n y si se relaciona temporalmente con la ultraestructural. Estudiar las modificaciones en los par\u00e1metros de funci\u00f3n global fg y comparar la magnitud y evoluci\u00f3n de \u00e9stos par\u00e1metros con los conocidos con un solo pi, am\u00e9n de observar si se producen alteraciones bioqu\u00edmicas en este modelo y sue voluci\u00f3n. Proponemos cuatro series con una y dos aplicacones delpi y distintos tiempos de seguimiento. Una serie sirve de control ultraestructural. Concluimos que la repetici\u00f3n de proceos breves de isquemia\/reperfusi\u00f3n sobre un miocardio previamente aturdido, duplica el periodo de tiempo del primer aturdimiento sin apreciarse modificaciones en los par\u00e1metros hemodin\u00e1micos de fg. Que paralelamente a ls modificaciones en la fr, en el \u00e1rea isqu\u00e9mica se observaron alteraciones ultraestructurales, sobre todo las que indican da\u00f1o mitocontrial, y que la tasa de dicho da\u00f1o aumenta progresivamente con la repectici\u00f3n del pi. Que el \u00e1rea control tambi\u00e9n muestra signos de da\u00f1o mitocondrial sin afectaci\u00f3n de su fr, en porcentaje signficativamente menor que en el \u00e1rea isqu\u00e9mica, como consecuenica del  aumento compensatorio en la tasa de renovaci\u00f3n mitocon<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cronificaci\u00f3n de la disfunci\u00f3n segmentaria mediante repetici\u00f3n de procesos breves de isquemia\/reperfusi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cronificaci\u00f3n de la disfunci\u00f3n segmentaria mediante repetici\u00f3n de procesos breves de isquemia\/reperfusi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Andr\u00e9s La Laguna Luis M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Cos\u00edn Aguilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Bayes de luna <\/li>\n<li>roberto Garcia civera (vocal)<\/li>\n<li>enrique Alborch dom\u00ednguez (vocal)<\/li>\n<li>Manuel Oya otero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s La Laguna Luis M. Nuestra hip\u00f3tesis consiste en que la miocardiopat\u00eda de origen isqu\u00e9mico, un mecanismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,139],"tags":[41951,20463,26966,41952,2097,11906],"class_list":["post-12869","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-medicina-interna","tag-andres-la-laguna-luis-m","tag-antonio-bayes-de-luna","tag-enrique-alborch-dominguez","tag-juan-cosin-aguilar","tag-manuel-oya-otero","tag-roberto-garcia-civera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=12869"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/12869\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=12869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=12869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=12869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}