{"id":128699,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-proteina-quinasas-pkc-raf-1-y-erk2-en-la-activacion-y-proliferacion-de-linfocitos-t\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"papel-de-las-proteina-quinasas-pkc-raf-1-y-erk2-en-la-activacion-y-proliferacion-de-linfocitos-t","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/papel-de-las-proteina-quinasas-pkc-raf-1-y-erk2-en-la-activacion-y-proliferacion-de-linfocitos-t\/","title":{"rendered":"Papel de las proteina quinasas pkc, raf-1 y erk2 en la activacion y proliferacion de linfocitos t."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Lisbona Laguna <\/strong><\/h2>\n<p>Los linfocitos t son celulas pertenecientes al sistema inmunitario que reconocen especificamente y actuan contra agentes extra\u00f1os al organismo, y median en la participacion de otras celulas en la respuesta inmune. La activacion y proliferacion de los mismos es un proceso altamente regulado por se\u00f1ales extra e intracelulares que han de transmitirse hasta el nucleo para que se produzca la division celular. Entre los mecanismos de transmision de se\u00f1ales destaca la fosforilacion de proteinas. En este trabajo se ha estudiado el papel de las proteina quinasas pkc, raf-1 y erk2 en la activacion y proliferacion de linfocitos t. Entre las conclusiones obtenidas mas importantes estan: en la transicion g1\/s del ciclo celular en la regulacion de erk2 intervienen fosfatasas de ser\/tre, trosina, duales. En el paso g1\/s, inducida por un ester de forbol, es necesaria la activacio sostenida de pkc, respondiendo de forma diferente entre si varias isoformas de pkc; la activacion de erk2 es necesaria pero no suficiente para la entrada en la fase s; raf-1 es necesaria, al menos, hasta un paso tardio para que la celula alcance la fase s; la activacion de erk2 es independiente de la hiperfosforilacion de raf-1, y ambas dependen de la actividad de pkc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las proteina quinasas pkc, raf-1 y erk2 en la activacion y proliferacion de linfocitos t.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las proteina quinasas pkc, raf-1 y erk2 en la activacion y proliferacion de linfocitos t. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Lisbona Laguna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarita Fern\u00e1ndez Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Teresa Miras Portugal <\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<li>Mar\u00eda  Isabel Fabregat Romero (vocal)<\/li>\n<li>Angeles Rebollo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Lisbona Laguna Los linfocitos t son celulas pertenecientes al sistema inmunitario que reconocen especificamente y actuan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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