{"id":128753,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aproximaciones-hacia-la-busqueda-de-mimeticos-de-colecistokinina\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"aproximaciones-hacia-la-busqueda-de-mimeticos-de-colecistokinina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aproximaciones-hacia-la-busqueda-de-mimeticos-de-colecistokinina\/","title":{"rendered":"Aproximaciones hacia la busqueda de mimeticos de colecistokinina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martin Martinez M. Mercedes <\/strong><\/h2>\n<p>En esta memoria se describe la sintesis y el estudio de la afinidad por los receptores de colecistoquinina (cck) de tres series de analogos conformacionalmente restringidos de boc- cck-4 (boc-trp-met-asp-phe-nh2) en los que el fragmento dipeptidico met-asp se ha sustituido por anillos de 2-oxopirrolidina, 6-oxoperhidropirrolo(1,2-a)pirazina y 1,3- dioxoperhidropirido (1,2-c) pirimidina, convenientemente sustituidos. Para acceder a las estructuras hererociclicas presentes en estos analogos de cck, se han desarrollado procedimientos sinteticos basados en reacciones de aminacion reductiva intramolecular a partir bien de 4-cetodiesteres derivados de dipeptidos (primera y segunda serie), o bien a partir de 3- cetoesteres derivados de ornitina (tercera serie). Desde el punto de vista quimico-medico la aportacion mas relevante de esta memoria es la obtencion de una nueva familia de antagonistas potentes y selectivos para los receptores ccka, dentro de los derivados portadores de un esqueleto de 1,3- dioxoperhidropirido (1,2-c) pirimidina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aproximaciones hacia la busqueda de mimeticos de colecistokinina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aproximaciones hacia la busqueda de mimeticos de colecistokinina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martin Martinez M. Mercedes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Rosario Gonz\u00e1lez Mu\u00f1iz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joaquin Plumet Ortega <\/li>\n<li>Joaquin Del Rio Zambrana (vocal)<\/li>\n<li>Jos\u00e9 Elguero Bertolini (vocal)<\/li>\n<li>David Andreu Mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martin Martinez M. Mercedes En esta memoria se describe la sintesis y el estudio de la afinidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[986,645,17,416],"tags":[5628,5626,1652,5627,5625,242057],"class_list":["post-128753","post","type-post","status-publish","format-standard","hentry","category-complutense-de-madrid","category-hidrocarburos-alifaticos","category-quimica","category-quimica-organica","tag-david-andreu-Martinez","tag-joaquin-del-rio-zambrana","tag-joaquin-plumet-ortega","tag-jose-elguero-bertolini","tag-maria-del-rosario-gonzalez-muniz","tag-martin-Martinez-m-mercedes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=128753"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/128753\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=128753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=128753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=128753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}