{"id":128754,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-la-actividad-cyp2d6-por-aminas-neurotransmisoras-posible-relacion-de-este-polimorfismo-con-la-transmision-serotoninergica\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"inhibicion-de-la-actividad-cyp2d6-por-aminas-neurotransmisoras-posible-relacion-de-este-polimorfismo-con-la-transmision-serotoninergica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inhibicion-de-la-actividad-cyp2d6-por-aminas-neurotransmisoras-posible-relacion-de-este-polimorfismo-con-la-transmision-serotoninergica\/","title":{"rendered":"Inhibicion de la actividad cyp2d6 por aminas neurotransmisoras. posible relacion de este polimorfismo con la transmision serotoninergica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Martin Molinero <\/strong><\/h2>\n<p>El citocromo p450 2d6 es una de las enzimas del organismo humano que se halla involucrada en el metabolismo de multiples sustancias extra\u00f1as al organismo, encontrandose en relacion con determinados tipos de canceres y\/o enfermedades. Mediante la utilizacion de microsomas hepaticos obtenidos a partir de higados humanos se ha demostrado la inhibicion de dicho enzima, valorada como o-demetilacion de dextrometorfan (sustrato del citocromo p450 2d6), por diversas aminas neurotransmisoras (adenalina, noradrenalina, dopamina, serotonina y triptamina) y compuestos relacionados con el metabolismo de las mismas. De entre las aminas capaces de producir inhibicion competitiva de la metabolizacion de dextrometorfan (caracteristica de los sustratos de dicho enzima), serotonina, dopamina y triptamina, solo la triptamina es metabolizada por la fraccion microsomal hepatica humana. El metabolismo de la triptamina por microsomas hepaticos es dependiente de la concentracion de nadph. El metabolismo de triptamina por los microsomas hepaticos humanos es inhibido de forma competitiva por diversos sustratos conocidos del citocromo p450 2d6, como debrisoquina, esparteina, bufuralol y dextrometorfan.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibicion de la actividad cyp2d6 por aminas neurotransmisoras. posible relacion de este polimorfismo con la transmision serotoninergica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibicion de la actividad cyp2d6 por aminas neurotransmisoras. posible relacion de este polimorfismo con la transmision serotoninergica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Martin Molinero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Benitez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Lorenzo Fernandez <\/li>\n<li>Pedro S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Alfonso Moreno Gonzalez (vocal)<\/li>\n<li>Antonio Garcia Garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Martin Molinero El citocromo p450 2d6 es una de las enzimas del organismo humano que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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